Antimicrobial Peptides

被引：1032

作者：

Bahar, Ali Adem ^{[1
,2
]}

Ren, Dacheng ^{[1
,2
,3
,4
]}

机构：

[1] Syracuse Univ, Dept Biomed & Chem Engn, Syracuse, NY 13244 USA

[2] Syracuse Univ, Syracuse Biomat Inst, Syracuse, NY 13244 USA

[3] Syracuse Univ, Dept Civil & Environm Engn, Syracuse, NY 13244 USA

[4] Syracuse Univ, Dept Biol, Syracuse, NY 13244 USA

来源：

PHARMACEUTICALS | 2013年 / 6卷 / 12期

基金：

美国国家科学基金会;

关键词：

antimicrobial peptide; biofilm; persister;

D O I：

10.3390/ph6121543

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The rapid increase in drug-resistant infections has presented a serious challenge to antimicrobial therapies. The failure of the most potent antibiotics to kill "superbugs" emphasizes the urgent need to develop other control agents. Here we review the history and new development of antimicrobial peptides (AMPs), a growing class of natural and synthetic peptides with a wide spectrum of targets including viruses, bacteria, fungi, and parasites. We summarize the major types of AMPs, their modes of action, and the common mechanisms of AMP resistance. In addition, we discuss the principles for designing effective AMPs and the potential of using AMPs to control biofilms (multicellular structures of bacteria embedded in extracellular matrixes) and persister cells (dormant phenotypic variants of bacterial cells that are highly tolerant to antibiotics).

引用

页码：1543 / 1575

页数：33

共 240 条

[1] Safety and efficacy of antimicrobial peptides against naturally acquired leishmaniasis [J].

Alberola, J ;

Rodríguez, A ;

Francino, O ;

Roura, X ;

Rivas, L ;

Andreu, D .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2004, 48 (02) :641-643

[2] Anti-HSV activity of lactoferrin and lactoferricin is dependent on the presence of heparan sulphate at the cell surface [J].

Andersen, JH ;

Jenssen, H ;

Sandvik, K ;

Gutteberg, TJ .

JOURNAL OF MEDICAL VIROLOGY, 2004, 74 (02) :262-271

[3] Bestowing antifungal and antibacterial activities by lipophilic acid conjugation to D,L-amino acid-containing antimicrobial peptides: A plausible mode of action [J].

Avrahami, D ;

Shai, Y .

BIOCHEMISTRY, 2003, 42 (50) :14946-14956

[4] Recognition of antimicrobial peptides by a bacterial sensor kinase [J].

Bader, MW ;

Sanowar, S ;

Daley, ME ;

Schneider, AR ;

Cho, US ;

Xu, WQ ;

Klevit, RE ;

Le Moual, H ;

Miller, S .

CELL, 2005, 122 (03) :461-472

[5] Immobilization Reduces the Activity of Surface-Bound Cationic Antimicrobial Peptides with No Influence upon the Activity Spectrum [J].

Bagheri, Mojtaba ;

Beyermann, Michael ;

Dathe, Margitta .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2009, 53 (03) :1132-1141

[6]

Balls A. K., 1942, CEREAL CHEM, V19, P279

[7] Mouse β-defensin 3 is an inducible antimicrobial peptide expressed in the epithelia of multiple organs [J].

Bals, R ;

Wang, XR ;

Meegalla, RL ;

Wattler, S ;

Weiner, DJ ;

Nehls, MC ;

Wilson, JM .

INFECTION AND IMMUNITY, 1999, 67 (07) :3542-3547

[8] Solution structure of Alo-3:: A new knottin-type antifungal peptide from the insect Acrocinus longimanus [J].

Barbault, F ;

Landon, C ;

Guenneugues, M ;

Meyer, JP ;

Schott, V ;

Dimarcq, JL ;

Vovelle, F .

BIOCHEMISTRY, 2003, 42 (49) :14434-14442

[9] Human α-defensin 1 (HNP-1) inhibits adenoviral infection in vitro [J].

Bastian, A ;

Schäfer, H .

REGULATORY PEPTIDES, 2001, 101 (1-3) :157-161

[10] Detergent-like properties of magainin antibiotic peptides:: A 31P solid-state NMR spectroscopy study [J].

Bechinger, B .

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 2005, 1712 (01) :101-108

← 1 2 3 4 5 6 7 8 9 10 →