CYTOKINES, PROSTAGLANDINS AND LIPOCORTIN-1 ARE PRESENT IN THE BRAINS OF SCRAPIE-INFECTED MICE

被引：94

作者：

WILLIAMS, AE

VANDAM, AM

MANAHING, WKH

BERKENBOSCH, F

EIKELENBOOM, P

FRASER, H

机构：

[1] FREE UNIV AMSTERDAM, FAC MED, NEUROSCI RES INST, DEPT PHARMACOL, 1081 BT AMSTERDAM, NETHERLANDS

[2] FREE UNIV AMSTERDAM, FAC MED, VALERIUSKLIN, DEPT PSYCHIAT, 1075 BG AMSTERDAM, NETHERLANDS

[3] INST ANIM HLTH, MRC, NEUROPATHOGENESIS UNIT, EDINBURGH EH9 3JF, MIDLOTHIAN, SCOTLAND

来源：

BRAIN RESEARCH | 1994年 / 654卷 / 02期

关键词：

SCRAPIE; CYTOKINE; PROSTAGLANDIN; LIPOCORTIN; ASTROCYTE; MOUSE; NEURODEGENERATION;

D O I：

10.1016/0006-8993(94)90480-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The presence of cytokines, prostaglandins and lipocortin-1 was investigated in terminally affected mice in two models of scrapie. There was marked induction of glial interleukin-1 beta, tumour necrosis factor alpha, prostaglandin E(2), prostaglandin F-2 alpha and lipocortin-1 immunoreactivity in those areas of the brain showing the characteristic vacuolation of scrapie. A comparison of these staining patterns with those of GFAP and F4/80 showed that their expression occurred predominantly in astrocytes. It is possible that cytokines play a significant role in the pathogenesis of neurodegeneration in scrapie.

引用

页码：200 / 206

页数：7

共 57 条

[1] IMMUNOCHEMICAL IDENTIFICATION OF THE SERINE PROTEASE INHIBITOR ALPHA-1-ANTICHYMOTRYPSIN IN THE BRAIN AMYLOID DEPOSITS OF ALZHEIMERS-DISEASE [J].