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CYTOKINES, PROSTAGLANDINS AND LIPOCORTIN-1 ARE PRESENT IN THE BRAINS OF SCRAPIE-INFECTED MICE

被引：94
作者：
WILLIAMS, AE
VANDAM, AM
MANAHING, WKH
BERKENBOSCH, F
EIKELENBOOM, P
FRASER, H
机构：
[1] FREE UNIV AMSTERDAM, FAC MED, NEUROSCI RES INST, DEPT PHARMACOL, 1081 BT AMSTERDAM, NETHERLANDS
[2] FREE UNIV AMSTERDAM, FAC MED, VALERIUSKLIN, DEPT PSYCHIAT, 1075 BG AMSTERDAM, NETHERLANDS
[3] INST ANIM HLTH, MRC, NEUROPATHOGENESIS UNIT, EDINBURGH EH9 3JF, MIDLOTHIAN, SCOTLAND
来源：
BRAIN RESEARCH | 1994年 / 654卷 / 02期
关键词：
SCRAPIE; CYTOKINE; PROSTAGLANDIN; LIPOCORTIN; ASTROCYTE; MOUSE; NEURODEGENERATION;
D O I：
10.1016/0006-8993(94)90480-4
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The presence of cytokines, prostaglandins and lipocortin-1 was investigated in terminally affected mice in two models of scrapie. There was marked induction of glial interleukin-1 beta, tumour necrosis factor alpha, prostaglandin E(2), prostaglandin F-2 alpha and lipocortin-1 immunoreactivity in those areas of the brain showing the characteristic vacuolation of scrapie. A comparison of these staining patterns with those of GFAP and F4/80 showed that their expression occurred predominantly in astrocytes. It is possible that cytokines play a significant role in the pathogenesis of neurodegeneration in scrapie.
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页码：200 / 206
页数：7
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