CLONAL ORIGIN OF PHILADELPHIA-CHROMOSOME NEGATIVE CELLS WITH TRISOMY-8 APPEARING DURING THE COURSE OF ALPHA-INTERFERON THERAPY FOR PH POSITIVE CHRONIC MYELOCYTIC-LEUKEMIA

被引：50

作者：

ARIYAMA, T

INAZAWA, J

UEMURA, Y

KAKAZU, N

MAEKAWA, T

URASE, F

IRIMAJIRI, K

HORIUCHI, A

NAKAMURA, Y

ABE, T

机构：

[1] KYOTO PREFECTURAL UNIV MED,DEPT HYG,KAMIGYO KU,KYOTO 602,JAPAN

[2] KINKI UNIV,SCH MED,DEPT INTERNAL MED 3,OSAKA,JAPAN

[3] JAPANESE FDN CANC RES,INST CANC,DEPT BIOCHEM,TOSHIMA KU,TOKYO 170,JAPAN

来源：

CANCER GENETICS AND CYTOGENETICS | 1995年 / 81卷 / 01期

关键词：

D O I：

10.1016/0165-4608(94)00197-9

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The transient appearance of a Philadelphia chromosome (Ph) negative clone with trisomy 8 was found in the bone marrow cells from a patient with Ph positive CML during the course of alpha-interferon (IFN) therapy. To determine whether this clone was derived from a Ph positive clone or from some other cell lineage, we performed molecular cytogenetic studies on bone marrow cells from the patient by fluorescence in situ hybridization (FISH). No fusion of BCR-ABL could be detected in cells with trisomy 8, clearly indicating that the Ph negative trisomy 8 clone was not derived from the Ph positive CML population.

引用

页码：20 / 23

页数：4

共 11 条

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