MALARIA TRANSMISSION-BLOCKING ACTIVITY IN EXPERIMENTAL INFECTIONS OF ANOPHELES-GAMBIAE FROM NATURALLY INFECTED PLASMODIUM-FALCIPARUM GAMETOCYTE CARRIERS

被引：45

作者：

MULDER, B

TCHUINKAM, T

DECHERING, K

VERHAVE, JP

CARNEVALE, P

MEUWISSEN, JHET

ROBERT, V

机构：

[1] UNIV NIJMEGEN, DEPT MED PARASITOL, 6500 HB NIJMEGEN, NETHERLANDS

[2] ORSTOM, OCEAC, MED ENTOMOL SERV, YAOUNDE, CAMEROON

[3] UNIV YAOUNDE, FAC SCI, YAOUNDE, CAMEROON

来源：

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE | 1994年 / 88卷 / 01期

关键词：

D O I：

10.1016/0035-9203(94)90534-7

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Experimental infections of anopheline mosquitoes were carried out with Plasmodium falciparum gametocytes from 65 naturally infected patients in Cameroon. A comparison was made between infections with blood containing autologous plasma and blood in which the plasma was replaced with plasma from a donor without previous malaria exposure. A lower infection rate was observed in 50 of 65 autologous plasma samples. Transmission was significantly blocked in 3 infections. This indicates that, in a population living in an area endemic for malaria, blood plasma factor(s) can reduce the transmission capacity of gametocyte carriers to mosquitoes.

引用

页码：121 / 125

页数：5

共 38 条

[1] RECOMBINANT PFS25 PROTEIN OF PLASMODIUM-FALCIPARUM ELICITS MALARIA TRANSMISSION-BLOCKING IMMUNITY IN EXPERIMENTAL-ANIMALS [J].