CONCENTRATION-DEPENDENT EFFECT OF IRON ON GAMMA-LINOLENIC ACID TOXICITY IN ZR-75-1 HUMAN BREAST-TUMOR CELLS IN CULTURE

被引:14
作者
CANTRILL, RC
ELLS, G
CHISHOLM, K
HORROBIN, DF
机构
[1] Efamol Research Institute, Kentville, NS
关键词
IRON; POLYUNSATURATED FATTY ACID; CYTOTOXICITY; HUMAN BREAST TUMOR CELLS; TISSUE CULTURE;
D O I
10.1016/0304-3835(93)90017-4
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Polyunsaturated fatty acids are cytotoxic to ZR-75-1 human breast tumor cells in culture. This effect may be potentiated by the simultaneous addition of iron. When cytotoxicity was measured in the presence of different concentrations of both gamma-linolenic acid and ferrous chloride there was an increase in cell death above concentrations of 9 muM and 0.05 muM, respectively. The potentiation of the effects of 18:3n-6 at low concentrations by the simultaneous addition of Fe(II) ions supports the contention that an alteration in the intracellular Fe(II)/Fe(III) ratio is necessary to promote autocatalytic lipid peroxidation.
引用
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页码:99 / 102
页数:4
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