PROTEIN DAMAGE CAUSED BY A SYNTHETIC ENEDIYNE CORE

被引：45

作者：

ZEIN, N ^{[1
]}

SOLOMON, W ^{[1
]}

CASAZZA, AM ^{[1
]}

KADOW, JF ^{[1
]}

KRISHNAN, BS ^{[1
]}

TUN, MM ^{[1
]}

VYAS, DM ^{[1
]}

DOYLE, TW ^{[1
]}

机构：

[1] DIV CHEM,WALLINGFORD,CT 06492

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1993年 / 3卷 / 06期

关键词：

PROTEIN DAMAGE; ENEDIYNE; DIRADICAL; ANTITUMOR; DNA;

D O I：

10.1016/S0960-894X(00)80347-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The simple enediyne core molecule 1 is shown to cause protein damage to several cellular protein isolates in vitro. The aromatization of 1 to generate a benzene diradical under simulated physiological conditions is also described.

引用

页码：1351 / 1356

页数：6

共 34 条

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[32] CALICHEAMICIN-GAMMA-1-I - AN ANTITUMOR ANTIBIOTIC THAT CLEAVES DOUBLE-STRANDED DNA SITE SPECIFICALLY [J].

ZEIN, N ;

SINHA, AM ;

MCGAHREN, WJ ;

ELLESTAD, GA .

SCIENCE, 1988, 240 (4856) :1198-1201

[33]

ZEIN N, UNPUB

[34]

ZEIN N, 1993, IN PRESS P NATL ACAD

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