SMOOTH-MUSCLE CELLS AND ATHEROSCLEROSIS

被引:19
作者
STEIN, O
STEIN, Y
机构
[1] HADASSAH UNIV HOSP, DIV MED, LIPID RES LAB, IL-91120 JERUSALEM, ISRAEL
[2] HEBREW UNIV JERUSALEM, DEPT EXPTL MED, JERUSALEM, ISRAEL
关键词
D O I
10.1097/00041433-199510000-00005
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The role of smooth muscle cells in atherogenesis involves cell proliferation and accretion of cholesteryl ester. Smooth muscle cell proliferation, controlled by growth factors produced locally, contributes to progression of atheroma and to restenosis after percutaneous transluminal coronary angioplasty. Accretion of cholesteryl ester in smooth muscle cells is mediated by factors secreted by macrophages. Induction of the scavenger receptor in smooth muscle cells may promote the transformation to roam cells. Novel approaches to combat restenosis include gene transfer into smooth muscle cells using different vectors.
引用
收藏
页码:269 / 274
页数:6
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