ANTICOAGULANT PROPERTIES OF PLACENTA PROTEIN-4 (ANNEXIN-V)

被引：54

作者：

ROMISCH, J

SCHORLEMMER, U

FICKENSCHER, K

PAQUES, EP

HEIMBURGER, N

机构：

[1] Research Laboratories, Behringwerke AG, D-3550 Marburg

来源：

THROMBOSIS RESEARCH | 1990年 / 60卷 / 05期

关键词：

PP4; LIPID-DEPENDENT INHIBITION; MEMBRANE-BINDING; THROMBOELASTOGRAPHY;

D O I：

10.1016/0049-3848(90)90218-2

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A placenta protein, originally termed PP4, was found to inhibit the aPTT in a concentration-dependent manner. PP4 which turned out to be identical with a vascular anticoagulant of the annexin type, inhibits the blood clotting process by binding of the essential lipids in a reaction which is dependent on calcium ions. Also in the presence of calcium PP4 combines with platelet membranes neutralizing their procoagulant effect. By fluorescence-microscopy binding of PP4 to stimulated macrophages is shown. The antithrombotic effect of PP4 is demonstrated by means of thrombelastography of human blood. Coagulation triggered by the addition of thromboplastin/lipid-mixtures is extinguished by PP4.

引用

页码：355 / 366

页数：12

共 23 条

[1] CHANGES IN MEMBRANE PHOSPHOLIPID DISTRIBUTION DURING PLATELET ACTIVATION [J].