ANTICOAGULANT PROPERTIES OF PLACENTA PROTEIN-4 (ANNEXIN-V)

被引：54

作者：

ROMISCH, J

SCHORLEMMER, U

FICKENSCHER, K

PAQUES, EP

HEIMBURGER, N

机构：

[1] Research Laboratories, Behringwerke AG, D-3550 Marburg

来源：

THROMBOSIS RESEARCH | 1990年 / 60卷 / 05期

关键词：

PP4; LIPID-DEPENDENT INHIBITION; MEMBRANE-BINDING; THROMBOELASTOGRAPHY;

D O I：

10.1016/0049-3848(90)90218-2

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A placenta protein, originally termed PP4, was found to inhibit the aPTT in a concentration-dependent manner. PP4 which turned out to be identical with a vascular anticoagulant of the annexin type, inhibits the blood clotting process by binding of the essential lipids in a reaction which is dependent on calcium ions. Also in the presence of calcium PP4 combines with platelet membranes neutralizing their procoagulant effect. By fluorescence-microscopy binding of PP4 to stimulated macrophages is shown. The antithrombotic effect of PP4 is demonstrated by means of thrombelastography of human blood. Coagulation triggered by the addition of thromboplastin/lipid-mixtures is extinguished by PP4.

引用

页码：355 / 366

页数：12

共 23 条

[21]

TAIT JF, 1989, J BIOL CHEM, V264, P7944

[22] PLACENTAL ANTICOAGULANT PROTEINS - ISOLATION AND COMPARATIVE CHARACTERIZATION OF 4 MEMBERS OF THE LIPOCORTIN FAMILY [J].

TAIT, JF ;

SAKATA, M ;

MCMULLEN, BA ;

MIAO, CH ;

FUNAKOSHI, T ;

HENDRICKSON, LE ;

FUJIKAWA, K .

BIOCHEMISTRY, 1988, 27 (17) :6268-6276

[23] STUDIES ON LEUKEMIC-CELL TISSUE FACTOR [J].

TANAKA, H ;

NARAHARA, N ;

KURABAYASHI, H ;

SADAKATA, H ;

ANDOH, K ;

UCHIYAMA, T ;

KOBAYASHI, N ;

MAEKAWA, T .

THROMBOSIS RESEARCH, 1989, 53 (06) :535-549

← 1 2 3 →