INVOLVEMENT OF GLYCOPROTEIN-C (GC) IN ADSORPTION OF HERPES-SIMPLEX VIRUS TYPE-1 (HSV-1) TO THE CELL

被引：52

作者：

SVENNERHOLM, B ^{[1
]}

JEANSSON, S ^{[1
]}

VAHLNE, A ^{[1
]}

LYCKE, E ^{[1
]}

机构：

[1] GOTHENBURG UNIV,DEPT CLIN VIROL,GULDHEDSAGAN 10B,S-41346 GOTHENBURG,SWEDEN

来源：

ARCHIVES OF VIROLOGY | 1991年 / 120卷 / 3-4期

关键词：

D O I：

10.1007/BF01310482

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Results demonstrating involvement of glycoprotein C (gC) of herpes simplex type 1 virus (HSV-1) in attachment of the virus to the cell are presented. Monoclonal antibodies against gC-1 inhibited adsorption of gC+-strains. The gC--mutant, MP, attached to cells but at a reduced rate. Attachment of the MP-mutant was unaffected by presence of anti-gC-1 antibody. Purified truncated gC-1 adsorbed to cells at a rate essentially the same as that of gC+-virus. Glycoprotein C-1 pretreated with heparin did not adsorb to cells. The results are compatible with a suggested role for gC in HSV attachment.

引用

页码：273 / 279

页数：7

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