LOCALIZATION OF THE FIBROBLAST GROWTH-FACTOR RECEPTOR-4 GENE TO CHROMOSOME REGION 5Q33-QTER

被引：16

作者：

ARMSTRONG, E

PARTANEN, J

CANNIZZARO, L

HUEBNER, K

ALITALO, K

机构：

[1] UNIV HELSINKI,DEPT PATHOL,CANC BIOL LAB,SF-00290 HELSINKI 29,FINLAND

[2] TEMPLE UNIV,HLTH SCI CTR,SCH MED,FELS INST CANC RES & MOLEC BIOL,PHILADELPHIA,PA 19140

来源：

GENES CHROMOSOMES & CANCER | 1992年 / 4卷 / 01期

关键词：

D O I：

10.1002/gcc.2870040116

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Our polymerase chain reaction cloning of novel tyrosine kinases expressed in the K562 chronic myeloid leukemia cells has revealed a novel fibroblast growth factor receptor, FGFR4. We have here mapped the FGFR4 gene by analysis of somatic cell hybrids and in situ hybridization to the 5q33-qter chromosomal region. This finding is of interest in that the FGFR4 gene is expressed in several leukemia cell lines and the 5q33-qter region is involved in nonrandom chromosomal translocations in acute myelogenous leukemias and Ki-1 lymphomas.

引用

页码：94 / 98

页数：5

共 34 条

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