A NEW TETRACYCLINE ANTIBIOTIC WITH ANTITUMOR-ACTIVITY .2. THE STRUCTURAL ELUCIDATION OF SF2575

被引：9

作者：

HATSU, M ^{[1
]}

SASAKI, T ^{[1
]}

GOMI, S ^{[1
]}

KODAMA, Y ^{[1
]}

SEZAKI, M ^{[1
]}

INOUYE, S ^{[1
]}

KONDO, S ^{[1
]}

机构：

[1] INST MICROBIAL CHEM,SHINAGAWA KU,TOKYO 141,JAPAN

来源：

JOURNAL OF ANTIBIOTICS | 1992年 / 45卷 / 03期

关键词：

D O I：

10.7164/antibiotics.45.325

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The structure of a new antitumor antibiotic SF2575, has been determined by spectroscopic analyses of the antibiotic and its alkaline degradation products. The relative stereochemistry has been confirmed by X-ray crystallographic analysis. The antibiotic has a 2-naphthacenecarboxamide carbon skelton which is structurally related to the tetracycline antibiotics and it is unique by bearing C-glycoside, salicylic acid and angelic acid moieties.

引用

收藏

页码：325 / 330

页数：6

相关论文

共 8 条

[1] C-13 NUCLEAR MAGNETIC-RESONANCE SPECTRAL ANALYSIS OF TETRACYCLINE HYDROCHLORIDE AND RELATED ANTIBIOTICS [J].

ASLESON, GL ;

FRANK, CW .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1975, 97 (21) :6246-6248

[2] MITHRIL - AN INTEGRATED DIRECT-METHODS COMPUTER-PROGRAM [J].

GILMORE, CJ .

JOURNAL OF APPLIED CRYSTALLOGRAPHY, 1984, 17 (FEB) :42-46

[3] A NEW TETRACYCLINE ANTIBIOTIC WITH ANTITUMOR-ACTIVITY .1. TAXONOMY AND FERMENTATION OF THE PRODUCING STRAIN, ISOLATION AND CHARACTERIZATION OF SF2575 [J].

HATSU, M ;

SASAKI, T ;

WATABE, H ;

MIYADOH, S ;

NAGASAWA, M ;

SHOMURA, T ;

SEZAKI, M ;

INOUYE, S ;

KONDO, S .

JOURNAL OF ANTIBIOTICS, 1992, 45 (03) :320-324

[4] ON THE APPLICATION OF PHASE-RELATIONSHIPS TO COMPLEX STRUCTURES .29. MAGIC-INTEGER REPRESENTATION OF A LARGE SET OF PHASES - THE MAGEX PROCEDURE [J].

HULL, SE ;

VITERBO, D ;

WOOLFSON, MM ;

ZHANG, SH .

ACTA CRYSTALLOGRAPHICA SECTION A, 1981, 37 (JUL) :566-572

[5]

MOTHERWELL WDS, PLUTO PROGRAM PLOTTI

[6] VICINAL C,H SPIN COUPLING IN SUBSTITUTED ALKENES - STEREOCHEMICAL SIGNIFICANCE AND STRUCTURAL EFFECTS [J].

VOGELI, U ;

PHILIPSBORN, WV .

ORGANIC MAGNETIC RESONANCE, 1975, 7 (12) :617-627

[7] USE OF C-13 IN BIOSYNTHETIC-STUDIES - ORIGIN OF THE MALONYL COENZYME-A INCORPORATED INTO TETRACYCLINE BY STREPTOMYCES-AUREOFACIENS [J].

WANG, IK ;

VINING, LC ;

WALTER, JA ;

MCINNES, AG .

JOURNAL OF ANTIBIOTICS, 1986, 39 (09) :1281-1287

[8] PROTON NUCLEAR MAGNETIC-RESONANCE STUDY OF SITE OF METAL BINDING IN TETRACYCLINE [J].

WILLIAMSON, DE ;

EVERETT, GW .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1975, 97 (09) :2397-2405