A NEW TETRACYCLINE ANTIBIOTIC WITH ANTITUMOR-ACTIVITY .1. TAXONOMY AND FERMENTATION OF THE PRODUCING STRAIN, ISOLATION AND CHARACTERIZATION OF SF2575

被引：32

作者：

HATSU, M ^{[1
]}

SASAKI, T ^{[1
]}

WATABE, H ^{[1
]}

MIYADOH, S ^{[1
]}

NAGASAWA, M ^{[1
]}

SHOMURA, T ^{[1
]}

SEZAKI, M ^{[1
]}

INOUYE, S ^{[1
]}

KONDO, S ^{[1
]}

机构：

[1] INST MICROBIAL CHEM, SHINAGAWA KU, TOKYO 141, JAPAN

来源：

JOURNAL OF ANTIBIOTICS | 1992年 / 45卷 / 03期

关键词：

D O I：

10.7164/antibiotics.45.320

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A new antitumor antibiotic SF2575 has been isolated from a culture filtrate of Streptomyces sp. SF2575. The molecular formula was determined to be C40H43NO15 by elemental analysis, mass and C-13 NMR spectral analyses. The spectral data revealed SF2575 to be a new tetracycline antibiotic. It was active against Gram-positive bacteria and exhibited antitumor activity against P388 leukemia in mice.

引用

页码：320 / 324

页数：5

共 4 条

[1] RAPID DIFFERENTIATION BETWEEN NOCARDIA + STREPTOMYCES BY PAPER CHROMATOGRAPHY OF WHOLE-CELL HYDROLYSATES [J].