MODIFIED HYDROXYAPATITE MICROSPHERES AS IMMUNOADSORBENT FOR PLASMA PERFUSION - PRELIMINARY-STUDY

被引：14

作者：

PAUL, W ^{[1
]}

SHARMA, CP ^{[1
]}

机构：

[1] SREE CHITRA TIRUNAL INST MED SCI & TECHNOL,BIOMED TECHNOL WING,DIV BIOSURFACE TECHNOL,TRIVANDRUM 695012,KERALA,INDIA

来源：

JOURNAL OF COLLOID AND INTERFACE SCIENCE | 1995年 / 174卷 / 01期

关键词：

D O I：

10.1006/jcis.1995.1385

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

An improved solid-support, affinity immunoadsorbent suitable for extracorporeal perfusion of plasma is reported. This consists of hydroxyapatite microspheres coated with a thin layer of poly(vinyl alcohol) and immobilized phenylalanine as ligand. This adsorbent can remove IgG immunoglobulins specifically from plasma. The modified adsorbent may be used for direct hemoperfusion as a cheaper alternative to plasma adsorption therapy by eliminating cell separator for selective removal of antibodies belonging to immunoglobulin G class. (C) 1995 Academic Press, Inc.

引用

页码：224 / 229

页数：6

共 33 条

[1]

AMERONGEN AVN, 1987, 13TH T ANN M SOC BIO, P108

[2]

AUTAIN J, 1977, ARTIF ORGANS, V1, P53

[3]

BYGREN P, 1985, LANCET, V11, P1295

[4] ELECTROPHORETIC ANALYSIS OF PROTEIN ADSORBED ON POLYMER SURFACES [J].

CHIU, TC ;

METCALF, LC ;

LYMAN, DJ .

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH, 1981, 15 (05) :781-784

[5] DISC ELECTROPHORESIS .2. METHOD AND APPLICATION TO HUMAN SERUM PROTEINS [J].

DAVIS, BJ .

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1964, 121 (A2) :404-&

[6] BIOLOGICAL CALCIUM PHOSPHATES AND THEIR ROLE IN THE PHYSIOLOGY OF BONE AND DENTAL TISSUES .1. COMPOSITION AND SOLUBILITY OF CALCIUM PHOSPHATES [J].

DRIESSENS, FCM ;

VANDIJK, JWE ;

BORGGREVEN, JMPM .

CALCIFIED TISSUE RESEARCH, 1978, 26 (02) :127-137

[7]

HEININGER K, 1987, THERAPEUTIC PLASMAPH, V6, P136

[8] BLOOD COMPATIBILITY OF HYDROPHILIC POLYMERS [J].

IKADA, Y ;

IWATA, H ;

HORII, F ;

MATSUNAGA, T ;

TANIGUCHI, M ;

SUZUKI, M ;

TAKI, W ;

YAMAGATA, S ;

YONEKAWA, Y ;

HANDA, H .

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH, 1981, 15 (05) :697-718

[9] ADSORPTION PROFILE OF COMMERCIALLY AVAILABLE ADSORBENTS - AN INVITRO EVALUATION [J].

IKONOMOV, V ;

SAMTLEBEN, W ;

SCHMIDT, B ;

BLUMENSTEIN, M ;

GURLAND, HJ .

INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS, 1992, 15 (05) :312-319

[10] INTERACTION OF SOME SERUM-PROTEINS WITH HYDROXYLAPATITE AND OTHER MATERIALS [J].

KLEIN, CPAT ;

DEGROOT, K ;

VERMEIDEN, JPW ;

VANKAMP, G .

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH, 1980, 14 (06) :705-712

← 1 2 3 4 →