Bio-surface engineering with DNA scaffolds for theranostic applications

被引：21

作者：

Wang, Xiwei ^{[1
]}

Lai, Wei ^{[1
]}

Man, Tiantian ^{[1
]}

Qu, Xiangmeng ^{[1
]}

Li, Li ^{[1
]}

Chandrasekaran, Arun Richard ^{[2
]}

Pei, Hao ^{[1
]}

机构：

[1] East China Normal Univ, Sch Chem & Mol Engn, Shanghai Key Lab Green Chem & Chem Proc, 500 Dongchuan Rd, Shanghai 200241, Peoples R China

[2] Confer Hlth Inc, 56 Roland St, Harlestown, MA 02143 USA

来源：

NANOFABRICATION | 2018年 / 4卷 / 01期

基金：

中国博士后科学基金; 美国国家科学基金会;

关键词：

DNA nanostructures; theranostic application; diagnostics; therapeutics; bio-surface programmable; biosensor;

D O I：

10.1515/nanofab-2018-0001

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Biosensor design is important to bioanalysis yet challenged by the restricted target accessibility at the biomolecule-surface (bio-surface). The last two decades have witnessed the appearance of various "art-like" DNA nanostructures in one, two, or three dimensions, and DNA nanostructures have attracted tremendous attention for applications in diagnosis and therapy due to their unique properties (e.g., mechanical flexibility, programmable control over their shape and size, easy and high-yield preparation, precise spatial addressability and biocompatibility). DNA nanotechnology is capable of providing an effective approach to control the surface functionality, thereby increasing the molecular recognition ability at the biosurface. Herein, we present a critical review of recent progress in the development of DNA nanostructures in one, two and three dimensions and highlight their biological applications including diagnostics and therapeutics. We hope that this review provides a guideline for bio-surface engineering with DNA nanostructures.

引用

页码：1 / 16

页数：16

共 132 条

[21] Sensitivity and specificity of metal surface-immobilized "molecular beacon" biosensors [J].