EFFECTS OF THYROTROPIN-RELEASING-HORMONE AND A RELATED ANALOG, CNK-602A, ON LONG-TERM POTENTIATION IN THE MOSSY FIBER-CA3 PATHWAY OF GUINEA-PIG HIPPOCAMPAL SLICES

被引：22

作者：

ISHIHARA, K ^{[1
]}

KATSUKI, H ^{[1
]}

KAWABATA, A ^{[1
]}

SASA, M ^{[1
]}

SATOH, M ^{[1
]}

TAKAORI, S ^{[1
]}

机构：

[1] KYOTO UNIV,FAC PHARMACEUT SCI,DEPT PHARMACOL,KYOTO 606,JAPAN

来源：

BRAIN RESEARCH | 1991年 / 554卷 / 1-2期

关键词：

THYROTROPIN-RELEASING HORMONE; THYROTROPIN-RELEASING HORMONE ANALOG; CNK-602A; LONG-TERM POTENTIATION; HIPPOCAMPUS; MOSSY FIBER; CA3; REGION; GUINEA PIG;

D O I：

10.1016/0006-8993(91)90190-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effects of thyrotropin-releasing hormone (TRH) and a related analog, CNK-602A, that induces the release of catecholamines, on long-term potentiation (LTP) of the population spike in mossy fiber-CA3 pathways were investigated in guinea pig hippocampal slices. TRH augmented LTP of the population spike at concentrations of 10(-6)-10(-5) M. CNK-602A also augmented LTP at concentrations of 10(-6)-10(-5) M in a dose-dependent manner. LTP in slices of the hippocampus obtained from animals given 6-hydroxydopamine (6-OHDA) intraventricularly was significantly lower than that in non-treated animals. However, both TRH and CNK-602A (10(-6) M) augmented LTP in slices from 6-OHDA-treated animals. These findings suggest that TRH and CNK-602A augment LTP in the mossy fiber-CA3 pathway without activating noradrenergic and/or dopaminergic fibers.

引用

页码：203 / 208

页数：6

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