PROGRESSIVE TRANSFORMATION OF THE CYTOSKELETON ASSOCIATED WITH NORMAL AGING AND ALZHEIMERS-DISEASE

被引：93

作者：

VICKERS, JC

DELACOURTE, A

MORRISON, JH

机构：

[1] CUNY MT SINAI SCH MED, DEPT NEUROBIOL, NEW YORK, NY 10029 USA

[2] CUNY MT SINAI SCH MED, DEPT GERIATR & ADULT DEV, NEW YORK, NY 10029 USA

[3] INSERM, U156, F-59045 LILLE, FRANCE

来源：

BRAIN RESEARCH | 1992年 / 594卷 / 02期

关键词：

ALZHEIMERS DISEASE; AGING; NEUROFIBRILLARY TANGLE; THIOFLAVINE; TAU; NEUROFILAMENT; DEMENTIA;

D O I：

10.1016/0006-8993(92)91134-Z

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Transitional and end-stage forms of neurofibrillary tangles associated with normal aging and Alzheimer's disease were identified using thioflavine staining combined with tau and neurofilament protein immunofluorescence. Normal aging was marked by transitional pathology in layer II of the entorhinal cortex but no neurofibrillary tangles in prefrontal cortex, whereas, in Alzheimer's disease cases, layer II entorhinal neurons had progressed to end-stage neurofibrillary tangles and the prefrontal cortex contained a high representation of transitional forms of the neurofibrillary tangle.

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页码：273 / 278

页数：6

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