THE ORIGIN OF THE LUTEINIZING-HORMONE-RELEASING HORMONE (LHRH) NEURONS IN NEWTS (CYNOPS-PYRRHOGASTER) - THE EFFECT OF OLFACTORY PLACODE ABLATION

被引:131
作者
MURAKAMI, S
KIKUYAMA, S
ARAI, Y
机构
[1] JUNTENDO UNIV, SCH MED, DEPT ANAT, TOKYO 113, JAPAN
[2] WASEDA UNIV, SCH EDUC, DEPT BIOL, SHINJUKU KU, TOKYO 169, JAPAN
关键词
LHRH-CONTAINING NEURONS; OLFACTORY PLACODE; ORIGIN; TERMINAL NERVE; DEVELOPMENT; CYNOPS-PYRRHOGASTER (URODELA);
D O I
10.1007/BF00384722
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Neurons containing luteinizing hormone-releasing hormone (LHRH) are first detected in newt embryos (Cynops pyrrhogaster) in the olfactory epithelium and ventromedial portion of the olfactory nerve, after which they sequentially appear in the intracerebral course of the terminal nerve at prometamorphosis, and in the septo-preoptic area at postmetamorphosis. In adults, however, LHRH-immunoreactive cells are rarely seen in the nasal region, and their distribution shifts into the brain, suggesting their migration. In order to ascertain the origin and possible migration route of these neurons in newt larvae, the effect of unilateral or bilateral olfactory placodectomy on the LHRH neuronal system has been studied. Removal of the olfactory placode results in the absence of LHRH-immunoreactive cells in the nasal and brain regions of the operated side, whereas the subsequent growth and the LHRH-immunoreactive cellular distribution in the contralateral side are identical to those of normal larvae. Following bilateral placodectomy, no LHRH immunoreactivity is detected on either side of the olfactory-brain axis. These results suggest that LHRH neurons of the newt, Cynops pyrrhogaster, originate in the olfactory placode and then migrate into the brain during embryonic development.
引用
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页码:21 / 27
页数:7
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