TIAPRIDE IN LEVODOPA-INDUCED INVOLUNTARY MOVEMENTS

被引：28

作者：

LEES, AJ ^{[1
]}

LANDER, CM ^{[1
]}

STERN, GM ^{[1
]}

机构：

[1] UNIV COLL HOSP LONDON,DEPT NEUROL,LONDON WC1E 6JJ,ENGLAND

来源：

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY | 1979年 / 42卷 / 04期

关键词：

D O I：

10.1136/jnnp.42.4.380

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Tiapride, a substituted benzamide derivative closely related to metoclopramide, reduced levodopa-induced peak dose involuntary movements in 16 patients with idiopathic Parkinson's disease. However, an unacceptable increase in disability from Parkinsonism with aggravation of end-of-dose akinesia led to its cessation in 14 patients. Tiapride had no effect on levodopa-induced early morning and 'off-period' segmental dystonia. These results fail to support the notion that levodopa-induced dyskinesias are caused by overstimulation of a separate group of dopamine receptors.

引用

页码：380 / 383

页数：4

共 18 条

[1]

BARBEAU A, 1975, LANCET, V1, P756

[2] EFFECT OF NEW DOPAMINE-BLOCKING AGENT (OXIPEROMIDE) ON DRUG-INDUCED DYSKINESIAS IN PARKINSONS-DISEASE AND SPONTANEOUS DYSKINESIAS [J].

BEDARD, P ;

PARKES, JD ;

MARSDEN, CD .

BRITISH MEDICAL JOURNAL, 1978, 1 (6118) :954-956

[3] EXCITATION-MEDIATING AND INHIBITION-MEDIATING DOPAMINE-RECEPTORS - NEW CONCEPT TOWARDS A BETTER UNDERSTANDING OF ELECTROPHYSIOLOGICAL, BIOCHEMICAL, PHARMACOLOGICAL, FUNCTIONAL AND CLINICAL DATA [J].

COOLS, AR ;

VANROSSUM, JM .

PSYCHOPHARMACOLOGIA, 1976, 45 (03) :243-254

[4]

COSTALL B, 1977, SEM HOP PARIS, V53, P72

[5] NEUROLEPTIC ANTAGONISM OF DYSKINETIC PHENOMENA [J].

COSTALL, B ;

NAYLOR, RJ .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1975, 33 (02) :301-312

[6] COMPARISON OF INVITRO AND INVIVO DOPAMINE RECEPTOR ANTAGONISM PRODUCED BY SUBSTITUTED BENZAMIDE DRUGS [J].

JENNER, P ;

ELLIOTT, PNC ;

CLOW, A ;

REAVILL, C ;

MARSDEN, CD .

JOURNAL OF PHARMACY AND PHARMACOLOGY, 1978, 30 (01) :46-48

[7] ATTEMPTED USE OF HALOPERIDOL IN TREATMENT OF L-DOPA INDUCED DYSKINESIAS [J].

KLAWANS, HL ;

WEINER, WJ .

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1974, 37 (04) :427-430

[8]

KLAWANS HL, 1973, PHARMACOLOGY EXTRAPY

[9] TARDIVE-DYSKINESIA ASSOCIATED WITH METOCLOPRAMIDE [J].

LAVY, S ;

MELAMED, E ;

PENCHAS, S .

BRITISH MEDICAL JOURNAL, 1978, 1 (6105) :77-78

[10]

LEES AJ, 1977, LANCET, V2, P1034

← 1 2 →