TIAPRIDE IN LEVODOPA-INDUCED INVOLUNTARY MOVEMENTS

被引：28

作者：

LEES, AJ ^{[1
]}

LANDER, CM ^{[1
]}

STERN, GM ^{[1
]}

机构：

[1] UNIV COLL HOSP LONDON,DEPT NEUROL,LONDON WC1E 6JJ,ENGLAND

来源：

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY | 1979年 / 42卷 / 04期

关键词：

D O I：

10.1136/jnnp.42.4.380

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Tiapride, a substituted benzamide derivative closely related to metoclopramide, reduced levodopa-induced peak dose involuntary movements in 16 patients with idiopathic Parkinson's disease. However, an unacceptable increase in disability from Parkinsonism with aggravation of end-of-dose akinesia led to its cessation in 14 patients. Tiapride had no effect on levodopa-induced early morning and 'off-period' segmental dystonia. These results fail to support the notion that levodopa-induced dyskinesias are caused by overstimulation of a separate group of dopamine receptors.

引用

页码：380 / 383

页数：4

共 18 条

[11] BACLOFEN IN PARKINSONS-DISEASE [J].

LEES, AJ ;

SHAW, KM ;

STERN, GM .

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1978, 41 (08) :707-708

[12]

LHERMITTE F, 1977, SEM HOP PARIS, V53, P9

[13] ACTION OF DOPAMINE ON NEURONES OF CAUDATE NUCLEUS [J].

MCLENNAN, H ;

YORK, DH .

JOURNAL OF PHYSIOLOGY-LONDON, 1967, 189 (03) :393-&

[14] HETEROGENEITY OF STRIATAL AND LIMBIC DOPAMINE INNERVATION - HIGHLY FLORESCENT ISLANDS IN DEVELOPING AND ADULT RATS [J].

OLSON, L ;

FUXE, K ;

SEIGER, A .

BRAIN RESEARCH, 1972, 44 (01) :283-+

[15]

ROBINSON OP, 1973, POSTGRAD MED J, V49, P77

[16]

STERN GM, 1979, S ERGOT COMPOUNDS

[17] METOCLOPRAMIDE AND PIMOZIDE IN PARKINSONS-DISEASE AND LEVODOPA-INDUCED DYSKINESIAS [J].

TARSY, D ;

PARKES, JD ;

MARSDEN, CD .

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1975, 38 (04) :331-335

[18]

T AM NEUROL ASSOC

← 1 2 →