YEAST ARTIFICIAL CHROMOSOMES (YACS) AND THE ANALYSIS OF COMPLEX GENOMES

被引：6

作者：

ANAND, R

机构：

[1] R. Anand is at the Biotechnology Department, ICI Pharmaceuticals, Macclesfield, Cheshire SK10 4TG, Alderley Park

来源：

TRENDS IN BIOTECHNOLOGY | 1992年 / 10卷 / 1-2期

关键词：

D O I：

10.1016/0167-7799(92)90165-R

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The development of yeast artificial chromosome (YAC) cloning vectors capable of carrying several hundred kilobase-pairs of DNA insert has greatly facilitated the study of complex genomes, and the cloning of large genes as single fragments. In addition, the ability to manipulate YAC sequences by homologous recombination makes this system extremely useful for the generation of disease models.

引用

页码：35 / 40

页数：6

共 58 条

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