IQ AND VARIATION IN THE NUMBER OF FRAGILE-X CGG REPEATS - NO ASSOCIATION IN A NORMAL SAMPLE

被引:10
作者
DANIELS, JK
OWEN, MJ
MCGUFFIN, P
THOMPSON, L
DETTERMAN, DK
CHORNEY, M
CHORNEY, K
SMITH, D
SKUDER, P
VIGNETTI, S
MCCLEARN, GE
PLOMIN, R
机构
[1] UNIV WALES COLL MED, DEPT PSYCHOL MED, CARDIFF CF4 4XN, S GLAM, WALES
[2] CASE WESTERN RESERVE UNIV, CLEVELAND, OH USA
[3] PENN STATE UNIV, UNIVERSITY PK, PA USA
关键词
D O I
10.1016/0160-2896(94)90052-3
中图分类号
B84 [心理学];
学科分类号
04 ; 0402 ;
摘要
Fragile X mental retardation is associated with an unstable expansion of a CGG repeat in the FMR-1 gene on the X chromosome (Xq27.3). We asked whether variation in the number of FMR-1 CGG repeats relates to IQ in the general population. FMR-1 CGG repeats were genotyped for three groups: low IQ (mean IQ = 71, N = 35), middle IQ (mean IQ = 103, N = 19), and high IQ (mean IQ = 137, N = 49). The IQ groups did not differ significantly in number of FMR-1 CGG repeats for males or females.
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页码:45 / 50
页数:6
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