STRESS-INDUCED OLIGOMERIZATION AND CHROMOSOMAL RELOCALIZATION OF HEAT-SHOCK FACTOR

被引：314

作者：

WESTWOOD, JT

CLOS, J

WU, C

机构：

[1] Laboratory of Biochemistry, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892

来源：

NATURE | 1991年 / 353卷 / 6347期

关键词：

D O I：

10.1038/353822a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The induction of heat-shock transcription factor (HSF) binding to DNA is accomplished by a heat-induced oligomerization. The transition to the induced state is accompanied by a chromosomal redistribution of HSF to the heat-shock puff sites. Over 150 additional chromosomal sites also accumulate HSF, including developmental loci that are repressed during heat shock. These findings suggest an unforeseen role for HSF as a repressor of normal gene activity during heat stress.

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页码：822 / 823

页数：2

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