STRESS-INDUCED OLIGOMERIZATION AND CHROMOSOMAL RELOCALIZATION OF HEAT-SHOCK FACTOR

被引：314

作者：

WESTWOOD, JT

CLOS, J

WU, C

机构：

[1] Laboratory of Biochemistry, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892

来源：

NATURE | 1991年 / 353卷 / 6347期

关键词：

D O I：

10.1038/353822a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The induction of heat-shock transcription factor (HSF) binding to DNA is accomplished by a heat-induced oligomerization. The transition to the induced state is accompanied by a chromosomal redistribution of HSF to the heat-shock puff sites. Over 150 additional chromosomal sites also accumulate HSF, including developmental loci that are repressed during heat shock. These findings suggest an unforeseen role for HSF as a repressor of normal gene activity during heat stress.

引用

收藏

页码：822 / 823

页数：2

相关论文

共 56 条

[31] STABLE BINDING OF DROSOPHILA HEAT-SHOCK FACTOR TO HEAD-TO-HEAD AND TAIL-TO-TAIL REPEATS OF A CONSERVED 5-BP RECOGNITION UNIT [J].

PERISIC, O ;

XIAO, H ;

LIS, JT .

CELL, 1989, 59 (05) :797-806

[32] MOLECULAR AND DEVELOPMENTAL CHARACTERIZATION OF THE HEAT-SHOCK COGNATE-4 GENE OF DROSOPHILA-MELANOGASTER [J].

PERKINS, LA ;

DOCTOR, JS ;

ZHANG, K ;

STINSON, L ;

PERRIMON, N ;

CRAIG, EA .

MOLECULAR AND CELLULAR BIOLOGY, 1990, 10 (06) :3232-3238

[33] MOLECULAR-CLONING AND EXPRESSION OF A HUMAN HEAT-SHOCK FACTOR, HSF1 [J].

RABINDRAN, SK ;

GIORGI, G ;

CLOS, J ;

WU, C .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (16) :6906-6910

[34] NEW PUFFING PATTERN INDUCED BY TEMPERATURE SHOCK AND DNP IN DROSOPHILA [J].

RITOSSA, F .

EXPERIENTIA, 1962, 18 (12) :571-&

[35]

SARGE KD, IN PRESS GENES DEV

[36] 3 TOMATO GENES CODE FOR HEAT-STRESS TRANSCRIPTION FACTORS WITH A REGION OF REMARKABLE HOMOLOGY TO THE DNA-BINDING DOMAIN OF THE YEAST HSF [J].

SCHARF, KD ;

ROSE, S ;

ZOTT, W ;

SCHOFF, F ;

NOVER, L .

EMBO JOURNAL, 1990, 9 (13) :4495-4501

[37] ISOLATION OF A CDNA FOR HSF2 - EVIDENCE FOR 2 HEAT-SHOCK FACTOR GENES IN HUMANS [J].

SCHUETZ, TJ ;

GALLO, GJ ;

SHELDON, L ;

TEMPST, P ;

KINGSTON, RE .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (16) :6911-6915

[38] THE E75 ECDYSONE-INDUCIBLE GENE RESPONSIBLE FOR THE 75B EARLY PUFF IN DROSOPHILA ENCODES 2 NEW MEMBERS OF THE STEROID-RECEPTOR SUPERFAMILY [J].

SEGRAVES, WA ;

HOGNESS, DS .

GENES & DEVELOPMENT, 1990, 4 (02) :204-219

[39] METHOD FOR DETERMINATION OF INSITU DISTRIBUTION OF CHROMOSOMAL-PROTEINS [J].

SILVER, LM ;

ELGIN, SCR .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1976, 73 (02) :423-427

[40] HEAT-SHOCK FACTOR AND THE HEAT-SHOCK RESPONSE [J].

SORGER, PK .

CELL, 1991, 65 (03) :363-366

← 1 2 3 4 5 6 →