INFLAMMATORY RESPONSE LINKED TO OXAZOLONE-INDUCED CUTANEOUS BASOPHIL HYPERSENSITIVITY - EFFECT OF DIFFERENT IMMUNOMODULATOR AND ANTI-INFLAMMATORY DRUGS

The potency of cytostatic and anti-inflammatory drugs was tested on the oxazolone-induced cutaneous basophil hypersensitivity (CBH) in mice. The challenge reaction was performed early after sensitization in order to minimize B-cell expression; exudative and cellular infiltration was estimated 6 h, 24 h and 48 h after challenge. The potency of drugs was tested at three different periods of immunization: 2 days before or after sensitization or before challenge. Cytostatics act mainly when cells are being committed, a corticoid acts on inflammation linked to committed cells, NSAIDs show inconstant anti-inflammatory effects on this test. d-Penicillamine and levamisole act in the same depressive profile in normal animals. Thus the CBH model appears to be relevant in studying drug activities on inflammation linked to T-cell expression. © 1979 Birkhäuser Verlag.