INFLAMMATORY RESPONSE LINKED TO OXAZOLONE-INDUCED CUTANEOUS BASOPHIL HYPERSENSITIVITY - EFFECT OF DIFFERENT IMMUNOMODULATOR AND ANTI-INFLAMMATORY DRUGS

被引:6
作者
BURE, J
DEGRAND, F
机构
[1] Institut de Recherches Servier, Suresnes, 82150
来源
AGENTS AND ACTIONS | 1979年 / 9卷 / 5-6期
关键词
D O I
10.1007/BF01968124
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The potency of cytostatic and anti-inflammatory drugs was tested on the oxazolone-induced cutaneous basophil hypersensitivity (CBH) in mice. The challenge reaction was performed early after sensitization in order to minimize B-cell expression; exudative and cellular infiltration was estimated 6 h, 24 h and 48 h after challenge. The potency of drugs was tested at three different periods of immunization: 2 days before or after sensitization or before challenge. Cytostatics act mainly when cells are being committed, a corticoid acts on inflammation linked to committed cells, NSAIDs show inconstant anti-inflammatory effects on this test. d-Penicillamine and levamisole act in the same depressive profile in normal animals. Thus the CBH model appears to be relevant in studying drug activities on inflammation linked to T-cell expression. © 1979 Birkhäuser Verlag.
引用
收藏
页码:534 / 542
页数:9
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