EXOGENOUS O-6-METHYLGUANINE INHIBITS ADDUCT REMOVAL AND SENSITIZES HUMAN-CELLS TO KILLING BY THE CHEMICAL CARCINOGEN N-METHYL-N'-NITRO-N-NITROSOGUANIDINE

被引:6
作者
BABICH, MA [1 ]
DAY, RS [1 ]
机构
[1] NCI,MOLEC CARCINOGENESIS LAB,BETHESDA,MD 20205
来源
MUTATION RESEARCH | 1987年 / 184卷 / 03期
关键词
D O I
10.1016/0167-8817(87)90023-X
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
引用
收藏
页码:245 / 254
页数:10
相关论文
共 45 条
[21]   REPAIR OF CHEMICAL CARCINOGEN-INDUCED DAMAGE IN DNA OF HUMAN-LYMPHOCYTES AND LYMPHOID-CELL LINES - STUDIES OF THE KINETICS OF REMOVAL OF O-6-METHYLGUANINE AND 3-METHYLADENINE [J].
LAWLEY, PD ;
HARRIS, G ;
PHILLIPS, E ;
IRVING, W ;
COLACO, CB ;
LYDYARD, PM ;
ROITT, IM .
CHEMICO-BIOLOGICAL INTERACTIONS, 1986, 57 (01) :107-121
[23]  
LAWLEY PD, 1974, MUTAT RES, V23, P283, DOI 10.1016/0165-1218(74)90091-3
[24]   DNA AS A TARGET OF ALKYLATING CARCINOGENS [J].
LAWLEY, PD .
BRITISH MEDICAL BULLETIN, 1980, 36 (01) :19-24
[25]  
LAWLEY PD, 1981, CHROMOSOME DAMAGE RE, P19
[27]   TIME COURSE OF 0-6-METHYLGUANINE REMOVAL FROM DNA OF N-METHYL-N-NITROSOUREA-TREATED HUMAN-FIBROBLASTS [J].
MEDCALF, ASC ;
LAWLEY, PD .
NATURE, 1981, 289 (5800) :796-798
[28]   MUTAGENICITY OF CARCINOGENIC METHYLATING AGENTS IS ASSOCIATED WITH A SPECIFIC DNA MODIFICATION [J].
NEWBOLD, RF ;
WARREN, W ;
MEDCALF, ASC ;
AMOS, J .
NATURE, 1980, 283 (5747) :596-599
[29]  
PEGG AE, 1983, J BIOL CHEM, V258, P2327
[30]   CROSS-LINKING OF DNA INDUCED BY CHLOROETHYLNITROSOUREA IS PREVENTED BY O-6-METHYLGUANINE-DNA METHYLTRANSFERASE [J].
ROBINS, P ;
HARRIS, AL ;
GOLDSMITH, I ;
LINDAHL, T .
NUCLEIC ACIDS RESEARCH, 1983, 11 (22) :7743-7758