INHIBITORY EFFECT OF SOMATOSTATIN ON ABNORMAL GH RESPONSE TO TRH IN PRIMARY HYPOTHYROIDISM

被引：5

作者：

BALDINI, M ^{[1
]}

CATANIA, A ^{[1
]}

ORSATTI, A ^{[1
]}

MANFREDI, MG ^{[1
]}

MOTTA, P ^{[1
]}

CANTALAMESSA, L ^{[1
]}

机构：

[1] UNIV MILAN,CATTEDRA SEMIOT MED 1,I-20122 MILAN,ITALY

来源：

EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY | 1992年 / 99卷 / 02期

关键词：

SOMATOSTATIN; GH; TRH; PRIMARY HYPOTHYROIDISM;

D O I：

10.1055/s-0029-1211140

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Thyrotropin releasing hormone (TRH) does not promote GH secretion in normal subjects but it stimulates GH in a proportion of hypothyroid patients. In this study the response of GH to thyrotropin releasing hormone (TRH) was evaluated in 21 patients with primary hypothyroidism of different origin: 12 with autoimmune thyroiditis, 3 idiopathic, 3 congenital, 3 iatrogenic. 11 of these patients had never been treated, the others were tested after a drug-free period of at least two weeks. Basal plasma concentration of GH was normal in all patients; after TRH administration. a significant increase in plasma GH was observed in 4 patients. In these responsive patients, somatostatin infusion inhibited the abnormal GH response to TRH. It is suggested that the abnormal GH response to TRH in primary hypothyroidism might be caused by a relative deficiency of somatostatinergic control, which is corrected by exogenous somatostatin administration.

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收藏

页码：80 / 83

页数：4

相关论文

共 20 条

[1] SOMATOMEDIN-C MEDIATES GROWTH-HORMONE NEGATIVE FEEDBACK BY EFFECTS ON BOTH THE HYPOTHALAMUS AND THE PITUITARY [J].

BERELOWITZ, M ;

SZABO, M ;

FROHMAN, LA ;

FIRESTONE, S ;

CHU, L ;

HINTZ, RL .

SCIENCE, 1981, 212 (4500) :1279-1281

[2]

BRAUMAN H, 1968, J CLIN ENDOCR METAB, V28, P302

[3] THYROTROPIN-RELEASING-HORMONE STIMULATION AND SOMATOSTATIN INHIBITION OF GROWTH-HORMONE SECRETION FROM PERFUSED RAT ADENOHYPOPHYSES [J].

CARLSON, HE ;

MARIZ, IK ;

DAUGHADAY, WH .

ENDOCRINOLOGY, 1974, 94 (06) :1709-1713

[4] GROWTH-HORMONE SECRETION AND PLASMA SOMATOMEDIN-C IN PRIMARY HYPOTHYROIDISM [J].

CHERNAUSEK, SD ;

UNDERWOOD, LE ;

UTIGER, RD ;

VANWYK, JJ .

CLINICAL ENDOCRINOLOGY, 1983, 19 (03) :337-344

[5] INCREASE IN PLASMA GROWTH-HORMONE LEVELS FOLLOWING THYROTROPIN-RELEASING-HORMONE INJECTION IN CHILDREN WITH PRIMARY HYPOTHYROIDISM [J].

COLLU, R ;

LEBOEUF, G ;

LETARTE, J ;

DUCHARME, JR .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1977, 44 (04) :743-747

[6] INSULIN-LIKE GROWTH-FACTOR AND ITS CARRIER PROTEIN IN HYPOPITUITARY AND HYPOTHYROID CHILDREN AND ADULTS [J].

DRAZNIN, B ;

BURSTEIN, PJ ;

HEINRICH, UE ;

JOHNSON, CB ;

EMLER, CA ;

SCHALCH, DS .

CLINICAL ENDOCRINOLOGY, 1980, 12 (02) :137-142

[7] PERSISTENT TRH-INDUCED GROWTH-HORMONE RELEASE AFTER SHORT-TERM AND LONG-TERM L-THYROXINE REPLACEMENT THERAPY IN PRIMARY CONGENITAL HYPOTHYROIDISM [J].

FAGGIANO, M ;

CRISCUOLO, T ;

GRAZIANI, M ;

IORIO, S ;

PISANO, G ;

SINISI, AA ;

SINISI, AM ;

BELLASTELLA, A .

CLINICAL ENDOCRINOLOGY, 1985, 23 (01) :61-66

[8] ESTIMATION OF SOMATOMEDIN-C LEVELS IN NORMALS AND PATIENTS WITH PITUITARY DISEASE BY RADIOIMMUNOASSAY [J].

FURLANETTO, RW ;

UNDERWOOD, LE ;

VANWYK, JJ ;

DERCOLE, AJ .

JOURNAL OF CLINICAL INVESTIGATION, 1977, 60 (03) :648-657

[9] HYPOTHALAMIC HORMONE INTERACTION IN ACROMEGALY [J].

GOMEZPAN, A ;

TUNBRIDGE, WMG ;

DUNS, A ;

HALL, R ;

BESSER, GM ;

COY, DH ;

SCHALLY, AV ;

KASTIN, AJ .

CLINICAL ENDOCRINOLOGY, 1975, 4 (05) :455-460

[10] RESPONSES TO THYROTROPIN-RELEASING HORMONE IN PATIENTS WITH RENAL-FAILURE AND AFTER INFUSION IN NORMAL MEN [J].

GONZALEZ.D ;

KASTIN, AJ ;

SCHALCH, DS ;

TORRESZA.M ;

PEREZPAS.E ;

KATO, A ;

SCHALLY, AV .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1973, 36 (01) :117-120