INHIBITORY EFFECT OF SOMATOSTATIN ON ABNORMAL GH RESPONSE TO TRH IN PRIMARY HYPOTHYROIDISM

被引：5

作者：

BALDINI, M ^{[1
]}

CATANIA, A ^{[1
]}

ORSATTI, A ^{[1
]}

MANFREDI, MG ^{[1
]}

MOTTA, P ^{[1
]}

CANTALAMESSA, L ^{[1
]}

机构：

[1] UNIV MILAN,CATTEDRA SEMIOT MED 1,I-20122 MILAN,ITALY

来源：

EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY | 1992年 / 99卷 / 02期

关键词：

SOMATOSTATIN; GH; TRH; PRIMARY HYPOTHYROIDISM;

D O I：

10.1055/s-0029-1211140

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Thyrotropin releasing hormone (TRH) does not promote GH secretion in normal subjects but it stimulates GH in a proportion of hypothyroid patients. In this study the response of GH to thyrotropin releasing hormone (TRH) was evaluated in 21 patients with primary hypothyroidism of different origin: 12 with autoimmune thyroiditis, 3 idiopathic, 3 congenital, 3 iatrogenic. 11 of these patients had never been treated, the others were tested after a drug-free period of at least two weeks. Basal plasma concentration of GH was normal in all patients; after TRH administration. a significant increase in plasma GH was observed in 4 patients. In these responsive patients, somatostatin infusion inhibited the abnormal GH response to TRH. It is suggested that the abnormal GH response to TRH in primary hypothyroidism might be caused by a relative deficiency of somatostatinergic control, which is corrected by exogenous somatostatin administration.

引用

页码：80 / 83

页数：4

共 20 条

[11]

GUISTINA G, 1984, J CLIN ENDOCR METAB, V38, P906

[12] INCREASE OF SERUM GROWTH-HORMONE CONCENTRATION FOLLOWING THYROTROPIN-RELEASING HORMONE INJECTION IN PATIENTS WITH ACROMEGALY OR GIGANTISM [J].