PEPTIDE SEQUENCES THAT TARGET CYTOSOLIC PROTEINS FOR LYSOSOMAL PROTEOLYSIS

被引：549

作者：

DICE, JF ^{[1
]}

机构：

[1] TUFTS UNIV,SCH VET MED,BOSTON,MA 02111

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1990年 / 15卷 / 08期

关键词：

D O I：

10.1016/0968-0004(90)90019-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Lysosomes take up and degrade intracellular proteins in cultured cells in response to serum deprivation, and in tissues of organisms in response to starvation. One mechanism by which proteins enter lysosomes for subsequent degradation requires that substrate proteins contain peptide sequences biochemically related to Lys-Phe-Glu-Arg-Gln (KFERQ). © 1990.

引用

页码：305 / 309

页数：5

共 29 条

[11] HOW ARE SUBSTRATES RECOGNIZED BY THE UBIQUITIN-MEDIATED PROTEOLYTIC SYSTEM
CIECHANOVER, A
SCHWARTZ, AL
[J]. TRENDS IN BIOCHEMICAL SCIENCES, 1989, 14 (12) : 483 - 488
[12] MOLECULAR DETERMINANTS OF PROTEIN HALF-LIVES IN EUKARYOTIC CELLS
DICE, JF
[J]. FASEB JOURNAL, 1987, 1 (05) : 349 - 357
[13] DICE JF, 1989, BIOCHEM SOC SYMP, V55, P45
[14] DICE JF, 1986, J BIOL CHEM, V261, P6853
[15] EFFECTS OF HORMONAL AND NUTRITIONAL CHANGES ON RATES OF SYNTHESIS AND DEGRADATION OF HEPATIC PHOSPHOFRUCTOKINASE ISOENZYMES
DUNAWAY, GA
WEBER, G
[J]. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1974, 162 (02) : 629 - 637
[16] THE UBIQUITIN SYSTEM - FUNCTIONS AND MECHANISMS
FINLEY, D
VARSHAVSKY, A
[J]. TRENDS IN BIOCHEMICAL SCIENCES, 1985, 10 (09) : 343 - 347
[17] EFFICIENT SATURATION MUTAGENESIS OF A PENTAPEPTIDE CODING SEQUENCE USING MIXED OLIGONUCLEOTIDES
GOFF, SA
SHORTRUSSELL, SR
DICE, JF
[J]. DNA-A JOURNAL OF MOLECULAR & CELLULAR BIOLOGY, 1987, 6 (04): : 381 - 388
[18] GONDA DK, 1989, J BIOL CHEM, V264, P16700
[19] GORDON PB, 1989, BIOCHEM SOC SYMP, V55, P129
[20] KOMINAMI E, 1983, J BIOL CHEM, V258, P6093

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