REGULATORY SEQUENCE NEAR THE 3' END OF SEA-URCHIN HISTONE GEMS

被引：73

作者：

BUSSLINGER, M

PORTMANN, R

BIRNSTIEL, ML

机构：

[1] Institut für Molekularbiologie II, Universität Zürich, 8057 Zürich, Winterthurerstr

来源：

NUCLEIC ACIDS RESEARCH | 1979年 / 6卷 / 09期

关键词：

D O I：

10.1093/nar/6.9.2997

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The 3′ flanking sequences of all five histone genes have been sequenced in the histone DNA clone h19 of the sea urchin Psammechinus miliaris. A large (23 bp) and a small (10 bp) conserved sequence was found by sequence comparison, some 29-40 bp downstream from the termination codon. 12 bases of the larger homology block show a dyad symmetry. The available sequences of clone h22 of the same species and those of the histone clones pSp2 and pSpl7 of Strongylocentrotus purpuratus, another sea urchin species, fit well into this comparison. Two types of sequences are involved in the dyad symmetry; one is H1, H3 and H4 specific, the other is H2A and H2B specific. If these conserved sequences are transcribed, a hairpin loop could form in the RNA molecules. This secondary structure might serve as a recognition signal for a regulatory protein. © 1979 Information Retrieval Limited.

引用

页码：2997 / 3008

页数：12

共 25 条

[1] DNA SEQUENCES CODING FOR H2B HISTONE OF PSAMMECHINUS-MILIARIS [J].