INCREASE IN FREE-RADICAL GENERATION AND LIPID-PEROXIDATION FOLLOWING CHEMOTHERAPY IN PATIENTS WITH CANCER

被引：203

作者：

SANGEETHA, P ^{[1
]}

DAS, UN ^{[1
]}

KORATKAR, R ^{[1
]}

SURYAPRABHA, P ^{[1
]}

机构：

[1] NIZAMS INST MED SCI,DEPT MED,HYDERABAD 500482,INDIA

来源：

FREE RADICAL BIOLOGY AND MEDICINE | 1990年 / 8卷 / 01期

关键词：

Anti-cancer drugs; Cyclophosphamide; Free radicals; Hydrogen peroxide; Lipid peroxidation; Melondialdehyde; Superoxide anion; Vincristine;

D O I：

10.1016/0891-5849(90)90139-A

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Several anti-cancer drugs are known to bring about their tumoricidal actions by a free radical dependent mechanism. Majority of the studies reported that adriamycin, mitomycin C, bleomycin, etc., augment free radical generation and lipid peroxidation process in vitro. Our results reported here suggest that following chemotherapy both stimulated and unstimulated human polymorphonuclear leukocytes generate increased amounts of superoxide anion and hydrogen peroxide. This was accompanied by increased formation of lipid peroxidation products as measured by thiobarbituric acid assay. These results confirm that many anti-cancer drugs augment free radical generation and lipid peroxidation even in an vivo situation. © 1990.

引用

页码：15 / 19

页数：5

共 24 条

[1]

Mimnaugh, Kennedy, Trush, Sinha, Adriamycin-enhanced membrane lipid peroxidation in isolated rat nuclei, Cancer Res., 45, pp. 3296-3304, (1988)

[2]

Mimnaugh, Trush, Bhatnagar, Gram, Enhancement of reactive oxygen-dependent mitochondrial membrane lipid peroxidation by the anticancer drug adriamycin, Biochem. Pharmacol., 34, pp. 847-856, (1985)

[3]

Rajagopalan, Politi, Sinha, Myers, Adriamycin-induced free radical formation in the perfused rat heart. Implications for cardiotoxicity, Cancer Res., 48, pp. 4766-4769, (1988)

[4]

Pritsos, Sartorelli, Generation of reactive oxygen radicals through bioactivation of mitomycin antibiotics, Cancer Res., 46, pp. 3528-3532, (1986)

[5]

Lown, Joshna, Chan, Reactive oxygen species leading to lipid peroxidation and DNA lesions implicated in the cytotoxic action of certain antitumor antibiotics, Free radicals, lipid peroxidation, and cancer, pp. 305-328, (1982)

[6]

Goormaghtigh, Chatelain, Caspers, Ruysschaert, Evidence of a complex between adriamycin derivatives and cardiolipin. Possible role in cardiotoxicity, Biochem. Pharmacol., 29, pp. 3003-3010, (1980)

[7]

Mailer, Petering, Inhibition of oxidative phosphorylation in tumor cells and mitochondria by daunomycin and adriamycin, Biochem. Pharmacol., 25, pp. 2085-2089, (1976)

[8]

Mimnaugh, Trush, Ginsburg, Hirokota, Gram, The effects of adriamycin in vitro and in vivo on hepatic microsomal drug metabolizing enzymes. Role of microsomal lipid peroxidation, Toxicol. Appl. Pharmacol., 61, pp. 313-325, (1981)

[9]

Ghezzi, Donelli, Pantarotto, Faccinetti, Garattini, Evidence for covalent binding of adrioamycin to rat liver microsomal peroxidations, Biochem. Pharmacol., 30, pp. 175-177, (1981)

[10]

Sinha, Trush, Kennedy, Mimnaugh, Enzymatic activation and binding of adriamycin to nuclear DNA, Cancer Res., 44, pp. 2892-2896, (1984)

← 1 2 3 →