INCREASE IN FREE-RADICAL GENERATION AND LIPID-PEROXIDATION FOLLOWING CHEMOTHERAPY IN PATIENTS WITH CANCER

被引：203

作者：

SANGEETHA, P ^{[1
]}

DAS, UN ^{[1
]}

KORATKAR, R ^{[1
]}

SURYAPRABHA, P ^{[1
]}

机构：

[1] NIZAMS INST MED SCI,DEPT MED,HYDERABAD 500482,INDIA

来源：

FREE RADICAL BIOLOGY AND MEDICINE | 1990年 / 8卷 / 01期

关键词：

Anti-cancer drugs; Cyclophosphamide; Free radicals; Hydrogen peroxide; Lipid peroxidation; Melondialdehyde; Superoxide anion; Vincristine;

D O I：

10.1016/0891-5849(90)90139-A

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Several anti-cancer drugs are known to bring about their tumoricidal actions by a free radical dependent mechanism. Majority of the studies reported that adriamycin, mitomycin C, bleomycin, etc., augment free radical generation and lipid peroxidation process in vitro. Our results reported here suggest that following chemotherapy both stimulated and unstimulated human polymorphonuclear leukocytes generate increased amounts of superoxide anion and hydrogen peroxide. This was accompanied by increased formation of lipid peroxidation products as measured by thiobarbituric acid assay. These results confirm that many anti-cancer drugs augment free radical generation and lipid peroxidation even in an vivo situation. © 1990.

引用

页码：15 / 19

页数：5

共 24 条

[21]

Das, Begin, Ells, Huang, Horrobin, Polyunsaturated fatty acids augment free radical generation in tumor cells in vitro, Biochem. Biophys. Res. Commun., 145, pp. 15-24, (1987)

[22]

Das, Ells, Begin, Horrobin, Uptake and distribution of cis-unsaturated fatty acids and their effect on free radical generation in normal and tumor cells in vitro, Free Radical Biol. Med., 3, pp. 9-16, (1987)

[23]

Pick, Keisari, A simple colorimetric method for the measurement of H202 produced by cells in culture, J. Immunol. Methods, 38, pp. 161-170, (1980)

[24]

Bernheim, Bernheim, Wilbur, The reaction between thiobarbituric acid and the oxidation products of certain lipids, J Biol Chem, 174, pp. 257-264, (1948)

← 1 2 3 →