LACK OF MODIFICATION BY NATURALLY-OCCURRING ANTIOXIDANTS OF 3,2'-DIMETHYL-4-AMINOBIPHENYL-INITIATED RAT PROSTATE CARCINOGENESIS

被引：30

作者：

NAKAMURA, A

SHIRAI, T

TAKAHASHI, S

OGAWA, K

HIROSE, M

ITO, N

机构：

[1] First Department of Pathology, Nagoya City University Medical School, Mizuho-ku, Nagoya, 467, 1 Kawasumi, Misuho-cho

来源：

CANCER LETTERS | 1991年 / 58卷 / 03期

关键词：

RAT PROSTATE CARCINOGENESIS; 3,2'-DIMETHYL-4-AMINOBIPHENYL; ANTIOXIDANTS; MODIFICATION;

D O I：

10.1016/0304-3835(91)90107-S

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The modifying effects of 6 naturally occurring antioxidants on 3,2'-dimethyl-4-aminobiphenyl (DMAB)-initiated rat prostate carcinogenesis were investigated in male F344 rats. Animals were pretreated with DMAB in a 20-week initiation protocol and then administered basal diet containing 0.8% catechol, 0.8% resorcinol, 0.8% hydroquinone, 2 ppm selenium, 2% gamma-orysanol or 1% alpha-tocopherol for 40 weeks. The experiment was terminated at week 60 for histopathological assessment of lesion development. Atypical hyperplasias and carcinomas of the prostate were observed in the ventral lobe in all groups treated with DMAB. However, the incidences of these lesions were not significantly different between carcinogen control and antioxidant-treated groups. There were also no significant increases or decreases in the incidences of tumors in any other organs.

引用

页码：241 / 246

页数：6

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