EXPRESSION OF THE C-MET/HEPATOCYTE GROWTH-FACTOR RECEPTOR GENE DURING RAT-LIVER REGENERATION INDUCED BY CARBON-TETRACHLORIDE

被引：24

作者：

ITO, T ^{[1
]}

HAYASHI, N ^{[1
]}

HORIMOTO, M ^{[1
]}

SASAKI, Y ^{[1
]}

TANAKA, Y ^{[1
]}

KANEKO, A ^{[1
]}

FUSAMOTO, H ^{[1
]}

KAMADA, T ^{[1
]}

机构：

[1] OSAKA UNIV,SCH MED,DEPT MED 1,FUKUSHIMA 1-1-50,FUKUSHIMA KU,OSAKA 553,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1993年 / 190卷 / 03期

关键词：

D O I：

10.1006/bbrc.1993.1129

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The hepatocyte growth factor is closely related to liver regeneration. And the c-met protooncogene is reported to encode a hepatocyte growth factor receptor. Little is known, however, about how the c-met gene is activated during liver regeneration. In this study, we demonstrated that expression of the c-met gene/hepatocyte growth factor gene was enhanced, with a distinct peak, following carbon tetrachloride administration, i.e., the gene expression was activated at 6 hours after the treatment, then decreased, and again increased. The present study suggested that this gene could be responding to liver regeneration and that the hepatocyte growth factor receptor plays an important role in regulating cell cycle progression prior to elevation of deoxynucleic acid synthesis during liver regeneration. © 1993 Academic Press.

引用

页码：870 / 874

页数：5

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