6-(SUBSTITUTED METHYLENE)PENEMS, POTENT BROAD-SPECTRUM INHIBITORS OF BACTERIAL BETA-LACTAMASE .2. RACEMIC FURYL AND THIENYL DERIVATIVES

被引：10

作者：

BROOM, NJP

COLEMAN, K

HUNTER, PA

OSBORNE, NF

机构：

[1] Beecham Pharmaceuticals, Chemotherapeutic Research Centre, Surrey, RH3 7AJ, Brockham Park, Betchworth

来源：

JOURNAL OF ANTIBIOTICS | 1990年 / 43卷 / 01期

关键词：

D O I：

10.7164/antibiotics.43.76

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A series of racemic 6-(substituted methylene)penems have been prepared. These compounds contain a 5-membered monoheteroaromatic ring at C-8. The antibacterial/synergistic and β-lactamase inhibitory activities of both E- and Z-isomers and 2-substituted derivatives are compared. © 1990, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.

引用

页码：76 / 82

页数：7

共 7 条

[1] 6-(SUBSTITUTED METHYLENE)PENEMS, POTENT BROAD-SPECTRUM INHIBITORS OF BACTERIAL BETA-LACTAMASE .1. RACEMIC 6-ETHYLIDENEPENEMS
BASKER, MJ
OSBORNE, NF
[J]. JOURNAL OF ANTIBIOTICS, 1990, 43 (01) : 70 - 75
[2] SYNTHESIS AND BETA-LACTAMASE INHIBITORY ACTIVITY OF 9-(2-AMIDOETHENYLTHIO)-9-DEOXY DERIVATIVES OF CLAVULANIC ACID
BROOKS, G
COLEMAN, K
DAVIES, JS
HUNTER, PA
[J]. JOURNAL OF ANTIBIOTICS, 1988, 41 (07) : 892 - 898
[3] BROOM N, 1982, Patent No. 46363
[4] A CONVENIENT SYNTHESIS OF RACEMIC 6-HYDROXYETHYL-2-ALKYLTHIO-SUBSTITUTED PENEMS
DININNO, F
MUTHARD, DA
RATCLIFFE, RW
CHRISTENSEN, BG
[J]. TETRAHEDRON LETTERS, 1982, 23 (35) : 3535 - 3538
[5] OSBORNE NF, 1984, Patent No. 120613
[6] Reading C, 1986, J Enzyme Inhib, V1, P83, DOI 10.3109/14756368609020108
[7] Richmond M H, 1973, Adv Microb Physiol, V9, P31, DOI 10.1016/S0065-2911(08)60376-8

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