THE ANTITHROMBOTIC EFFECT OF LOW-MOLECULAR-WEIGHT SYNTHETIC THROMBIN INHIBITORS, ARGATROBAN AND PPACK, ON HE-NE LASER-INDUCED THROMBOSIS IN RAT MESENTERIC MICROVESSELS

被引：18

作者：

YAMASHITA, T

YAMAMOTO, J

SASAKI, Y

MATSUOKA, A

机构：

[1] HYOGO MED UNIV,DEPT CLIN PATHOL,NISHINOMIYA,HYOGO 663,JAPAN

[2] HYOGO MED UNIV,CLIN LABS,NISHINOMIYA,HYOGO 663,JAPAN

来源：

THROMBOSIS RESEARCH | 1993年 / 69卷 / 01期

关键词：

THROMBIN INHIBITOR; ARGATROBAN; PPACK; LASER; THROMBOSIS;

D O I：

10.1016/0049-3848(93)90006-A

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The antithrombotic effect of low molecular weight synthetic thrombin inhibitors, argatroban ((2R, 4R)-4-methyl-1-[N2-[(3-methyl-1, 2, 3, 4-tetrahydro-8-quinolinesulfonyl)-L-arginyl]-2-piperidinecarboxylic acid monohydrate]) and PPACK (D-phenylalanyl-L-prolyl-L-arginyl-chloromethyl ketone) on He-Ne laser-induced thrombosis in rat mesenteric microvessels was studied. Both inhibitors showed a significant antithrombotic effect at 0.5 mg/kg which lasted for 50 min and 50-60 min using argatroban and PPACK, respectively. A dose-dependent effect was observed in arterioles and venules. The results suggest that thrombin plays an important role in the formation of a platelet thrombus in vivo.

引用

页码：93 / 100

页数：8