MATERNAL DRINKING DURING PREGNANCY - ATTENTION AND SHORT-TERM-MEMORY IN 14-YEAR-OLD OFFSPRING - A LONGITUDINAL PROSPECTIVE-STUDY

被引:259
作者
STREISSGUTH, AP
SAMPSON, PD
OLSON, HC
BOOKSTEIN, FL
BARR, HM
SCOTT, M
FELDMAN, J
MIRSKY, AF
机构
[1] UNIV WASHINGTON, DEPT STAT, SEATTLE, WA 98195 USA
[2] UNIV WASHINGTON, DEPT PSYCHOL, SEATTLE, WA 98195 USA
[3] UNIV MICHIGAN, CTR HUMAN GROWTH & DEV, ANN ARBOR, MI 48109 USA
[4] NIMH, PSYCHOL & PSYCHOPATHOL LAB, BETHESDA, MD 20892 USA
关键词
FETAL ALCOHOL EFFECTS; BEHAVIORAL TERATOLOGY; ALCOHOL; ADOLESCENT DEVELOPMENT; ATTENTION;
D O I
10.1111/j.1530-0277.1994.tb00904.x
中图分类号
R194 [卫生标准、卫生检查、医药管理];
学科分类号
摘要
A large and compelling experimental literature has documented the adverse impact of prenatal alcohol exposure on the developing brain of the offspring. This is the first report of adolescent attention/ memory performance and its relationship with prenatal alcohol exposure in a population-based, longitudinal, prospective study (n 462) involving substantial covariate control and ''blind'' examiners. Prenatal alcohol exposure was significantly related to attention/ memory deficits in a dose-dependent fashion. A latent variable reflecting 13 measures of maternal drinking was correlated 0.26 with a latent variable representing 52 scores from 6 tests measuring various components of attention and short-term memory performance. The number of drinks/occasion was the strongest alcohol predictor. Fluctuating attentional states, problems with response inhibition, and spatial learning showed the strongest association with prenatal alcohol exposure. A latent variable reflecting the pattern of attention/memory deficits observed at 14 years correlated 0.67 with a composite pattern of deficits previously detected on neurobehavioral tests administered during the first 7 years of life. The 14-year attention/memory deficits observed in the present study appear to be the adolescent sequelae of deficits observed earlier in development. As is usual in such studies, not all exposed offspring showed deficits.
引用
收藏
页码:202 / 218
页数:17
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