ROLE OF CD40-CD40-LIGAND INTERACTION IN LG-ISOTYPE SWITCHING

被引：56

作者：

FULEIHAN, R

RAMESH, N

GEHA, RS

机构：

[1] The Children's Hospital, Harvard Medical School, Boston

来源：

CURRENT OPINION IN IMMUNOLOGY | 1993年 / 5卷 / 06期

关键词：

D O I：

10.1016/0952-7915(93)90113-7

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Ig-isotype switching to IgE requires interleukin-4 and a contact-dependent T-cell signal delivered by the ligand for CD40. The recent discovery that defects in the gene encoding the CD40 ligand are the underlying cause of the X-linked hyper IgM syndrome highlights the role of CD40 and its ligand in Ig-isotype switching.

引用

页码：963 / 967

页数：5

共 44 条

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