NEW ADVANCED ANALYTICAL TOOLS IN PEPTIDE/PROTEIN RESEARCH - MATRIX-ASSISTED LASER-DESORPTION MASS-SPECTROMETRY

被引:7
作者
VANVEELEN, PA
JIMENEZ, CR
LI, KW
GERAERTS, WPM
TJADEN, UR
VANDERGREEF, J
机构
[1] FREE UNIV AMSTERDAM,FAC BIOL,NEUROSCI RES INST,GRAD SCH NEUROSCI,1081 HV AMSTERDAM,NETHERLANDS
[2] TNO,IBC,CTR STRUCT ELUCIDAT & INSTRUMENTAL ANAL,3700 AJ ZEIST,NETHERLANDS
关键词
D O I
10.1016/0168-3659(94)90069-8
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Some possibilities of matrix assisted laser desorption ionization mass spectrometry (MALDI-MS) are discussed with emphasis on the analysis of very small sample volumes. Preliminary results on the analysis of peptides in single neurons are presented as well as the combination of capillary electrophoresis MALDI-MS.
引用
收藏
页码:223 / 229
页数:7
相关论文
共 12 条
[1]   WEIGHING NAKED PROTEINS - PRACTICAL, HIGH-ACCURACY MASS MEASUREMENT OF PEPTIDES AND PROTEINS [J].
CHAIT, BT ;
KENT, SBH .
SCIENCE, 1992, 257 (5078) :1885-1894
[2]   PLASMA DESORPTION MASS-SPECTROMETRY - COMING OF AGE [J].
COTTER, RJ .
ANALYTICAL CHEMISTRY, 1988, 60 (13) :A781-&
[3]   CHEMICAL ASPECTS OF FAST-ATOM-BOMBARDMENT [J].
FENSELAU, C ;
COTTER, RJ .
CHEMICAL REVIEWS, 1987, 87 (03) :501-512
[4]   LASER DESORPTION IONIZATION OF PROTEINS WITH MOLECULAR MASSES EXCEEDING 10000 DALTONS [J].
KARAS, M ;
HILLENKAMP, F .
ANALYTICAL CHEMISTRY, 1988, 60 (20) :2299-2301
[5]   MICROCOLUMN SEPARATIONS AND THE ANALYSIS OF SINGLE CELLS [J].
KENNEDY, RT ;
OATES, MD ;
COOPER, BR ;
NICKERSON, B ;
JORGENSON, JW .
SCIENCE, 1989, 246 (4926) :57-63
[6]   QUANTITATIVE-DETERMINATION OF NATIVE PROTEINS IN INDIVIDUAL HUMAN ERYTHROCYTES BY CAPILLARY ZONE ELECTROPHORESIS WITH LASER-INDUCED FLUORESCENCE DETECTION [J].
LEE, TT ;
YEUNG, ES .
ANALYTICAL CHEMISTRY, 1992, 64 (23) :3045-3051
[7]   ELECTROSPRAY - ITS POTENTIAL AND LIMITATIONS AS AN IONIZATION METHOD FOR BIOMOLECULES [J].
MANN, M .
ORGANIC MASS SPECTROMETRY, 1990, 25 (11) :575-587
[8]  
NIESSEN WMA, 1991, LIQUID CHROMATOGRAPH, V58
[9]   CAPILLARY ELECTROPHORESIS IN 2-MU-M AND 5-MU-M DIAMETER CAPILLARIES - APPLICATION TO CYTOPLASMIC ANALYSIS [J].
OLEFIROWICZ, TM ;
EWING, AG .
ANALYTICAL CHEMISTRY, 1990, 62 (17) :1872-1876
[10]   2,5-DIHYDROXYBENZOIC ACID - A NEW MATRIX FOR LASER DESORPTION IONIZATION MASS-SPECTROMETRY [J].
STRUPAT, K ;
KARAS, M ;
HILLENKAMP, F .
INTERNATIONAL JOURNAL OF MASS SPECTROMETRY AND ION PROCESSES, 1991, 111 :89-102