NUCLEOTIDE-SEQUENCE OF AMPICILLIN RESISTANCE GENE OF ESCHERICHIA-COLI PLASMID PBR322

被引:789
作者
SUTCLIFFE, JG [1 ]
机构
[1] HARVARD UNIV,BIOL LABS,CAMBRIDGE,MA 02138
关键词
D O I
10.1073/pnas.75.8.3737
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The nucleotide sequence of the ampicillin resistance gene of pBR322, an E. coli plasmid that encodes a penicillin β-lactamase, was determined. This gene codes for a protein of 286 amino acid residues. The first 23 amino acids presumably form a signal for secretion, because they do not appear in the mature enzyme, whose partial amino acid sequence has been determined independently.
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页码:3737 / 3741
页数:5
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