RELEASE OF CHOLECYSTOKININ PEPTIDES FROM A SYNAPTOSOME-ENRICHED FRACTION OF RAT CEREBRAL-CORTEX

被引：159

作者：

PINGET, M ^{[1
]}

STRAUS, E ^{[1
]}

YALOW, RS ^{[1
]}

机构：

[1] CUNY MT SINAI SCH MED,NEW YORK,NY 10029

来源：

LIFE SCIENCES | 1979年 / 25卷 / 04期

关键词：

D O I：

10.1016/0024-3205(79)90264-9

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Cholecystokinin (CCK) and its C-terminal fragments have been shown previously to be concentrated in synaptosome-rich subcellular fractions from rat brain. In this report we demonstrate that release of immunoreactive CCK is increased by 200% in solutions containing K+ and Ca++ according to the paradigms usually employed to evaluate neuronal chemicals purported to have a role in synaptic physiology. This strengthens our hypothesis that CCK has a role in synaptic function. © 1979.

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页码：339 / 342

页数：4

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共 11 条

[1] VASOACTIVE INTESTINAL POLYPEPTIDE IN BRAIN - LOCALIZATION IN AND RELEASE FROM ISOLATED NERVE-TERMINALS [J].

GIACHETTI, A ;

SAID, SI ;

REYNOLDS, RC ;

KONIGES, FC .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1977, 74 (08) :3424-3428

[2] CHOLECYSTOKININ AND ITS COOH-TERMINAL OCTAPEPTIDE IN PIG BRAIN [J].

MULLER, JE ;

STRAUS, E ;

YALOW, RS .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1977, 74 (07) :3035-3037

[3] LOCALIZATION OF CHOLECYSTOKININ-LIKE IMMUNOREACTIVITY IN ISOLATED NERVE-TERMINALS [J].

PINGET, M ;

STRAUS, E ;

YALOW, RS .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1978, 75 (12) :6324-6326

[4] RELEASE OF SUBSTANCE-P FROM ISOLATED NERVE-ENDINGS [J].

SCHENKER, C ;

MROZ, EA ;

LEEMAN, SE .

NATURE, 1976, 264 (5588) :790-792

[5] CHOLECYSTOKININ IN BRAINS OF OBESE AND NON-OBESE MICE [J].

STRAUS, E ;

YALOW, RS .

SCIENCE, 1979, 203 (4375) :68-69

[6] IMMUNOHISTOCHEMICAL LOCALIZATION IN RABBIT BRAIN OF A PEPTIDE RESEMBLING COOH-TERMINAL OCTAPEPTIDE OF CHOLECYSTOKININ [J].

STRAUS, E ;

MULLER, JE ;

CHOI, HS ;

PARONETTO, F ;

YALOW, RS .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1977, 74 (07) :3033-3034

[7] SPECIES SPECIFICITY OF CHOLECYSTOKININ IN GUT AND BRAIN OF SEVERAL MAMMALIAN-SPECIES [J].

STRAUS, E ;

YALOW, RS .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1978, 75 (01) :486-489

[8]

STRAUS E, LIFE SCI

[9] RELEASE OF LUTEINIZING-HORMONE RELEASING HORMONE AND THYROTROPIN RELEASING HORMONE FROM A SYNAPTOSOME-ENRICHED FRACTION OF HYPOTHALAMIC HOMOGENATES [J].

WARBERG, J ;

ESKAY, RL ;

BARNEA, A ;

REYNOLDS, RC ;

PORTER, JC .

ENDOCRINOLOGY, 1977, 100 (03) :814-825

[10] CRITERIA FOR IDENTIFICATION OF A CENTRAL NERVOUS SYSTEM TRANSMITTER [J].

WERMAN, R .

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY, 1966, 18 (04) :745-&