HYDROFLUORINATION OF ANHYDROTHYMIDINE VIA SOLUBLE ALUMINUM DERIVATIVES

被引：15

作者：

GREEN, K

BLUM, DM

机构：

[1] Department of Chemical Process Development, Medical Research Division, American Cyanamid Co., Pearl River

来源：

TETRAHEDRON LETTERS | 1991年 / 32卷 / 19期

关键词：

D O I：

10.1016/S0040-4039(00)71244-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new method to stereospecifically hydrofluorinate anhydrothymidine has been discovered which allows the product to be obtained in higher yields than the current literature method.

引用

页码：2091 / 2094

页数：4

共 8 条

[1] SYNTHESIS AND BIOLOGICAL-ACTIVITY OF 5-FLUORO-2',3'-DIDEOXY-3'-FLUOROURIDINE AND ITS 5'-PHOSPHATE
AJMERA, S
BAPAT, AR
DANENBERG, K
DANENBERG, PV
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1984, 27 (01) : 11 - 14
[2] ANTI-RETROVIRUS ACTIVITY OF 3'-FLUORO-SUBSTITUTED AND 3'-AZIDO-SUBSTITUTED PYRIMIDINE 2',3'-DIDEOXYNUCLEOSIDE ANALOGS
BALZARINI, J
BABA, M
PAUWELS, R
HERDEWIJN, P
DECLERCO, E
[J]. BIOCHEMICAL PHARMACOLOGY, 1988, 37 (14) : 2847 - 2856
[3] Boswell G. A., 1974, ORG REACTIONS, V21, P1
[4] Dmowski J, 1985, ORG REACTIONS, V34, P319
[5] NUCLEOSIDES OF FLUORO SUGARS .6. SYNTHESIS AND REACTIVITY OF 3'-FLUORO-3'-DESOXYTHYMIDINE AND 3'-CHLORO-3'-DESOXYTHYMIDINE
ETZOLD, G
HINTSCHE, R
KOWOLLIK, G
LANGEN, P
[J]. TETRAHEDRON, 1971, 27 (12) : 2463 - &
[6] Henne A. L., 1944, ORG REACT, V2, P49
[7] 3'-SUBSTITUTED 2',3'-DIDEOXYNUCLEOSIDE ANALOGS AS POTENTIAL ANTI-HIV (HTLV-III/LAV) AGENTS
HERDEWIJN, P
BALZARINI, J
DECLERCQ, E
PAUWELS, R
BABA, M
BRODER, S
VANDERHAEGHE, H
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1987, 30 (08) : 1270 - 1278
[8] Hudlicky M., 1988, ORG REACTIONS, V35, P513, DOI DOI 10.1002/0471264180.0R035.03

← 1 →