STRUCTURE OF THE MOUSE 5-HT1C, 5-HT2 AND STOMACH FUNDUS SEROTONIN RECEPTOR GENES

被引：63

作者：

FOGUET, M ^{[1
]}

NGUYEN, H ^{[1
]}

LE, H ^{[1
]}

LUBBERT, H ^{[1
]}

机构：

[1] SANDOZ PHARMA LTD,PRECLIN RES,CH-4002 BASEL,SWITZERLAND

来源：

NEUROREPORT | 1992年 / 3卷 / 04期

关键词：

SPLICING; G-PROTEIN COUPLED RECEPTOR; MOLECULAR CLONING; INVERSE PCR; EVOLUTION;

D O I：

10.1097/00001756-199204000-00014

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

BY analysis of the mouse 5-HT1C receptor gene we found that its coding region contains three introns. We next isolated cDNA and genomic clones for the closely related 5-HT2 receptor using a probe derived from the 5-HT1C receptor sequence. This probe also hybridized to an additional gene, called SRL (Serotonin Receptor Like). We have evidence demonstrating that it encodes the stomach fundus 5-HT receptor. Two introns are present within the coding regions of the mouse 5-HT2 receptor gene and the SRL gene at positions which correspond to those of introns in the 5-HT1C receptor gene. This intron distribution is unique and distinguishes these receptors from other members of the family of receptors coupled to G-proteins.

引用

页码：345 / 348

页数：4

共 17 条

[1] BAEZ M, 1990, MOL PHARMACOL, V38, P31
[2] THE MOLECULAR-BASIS OF MUSCARINIC RECEPTOR DIVERSITY
BONNER, TI
[J]. TRENDS IN NEUROSCIENCES, 1989, 12 (04) : 148 - 151
[3] THE DOPAMINE-D2 RECEPTOR - 2 MOLECULAR-FORMS GENERATED BY ALTERNATIVE SPLICING
DALTOSO, R
SOMMER, B
EWERT, M
HERB, A
PRITCHETT, DB
BACH, A
SHIVERS, BD
SEEBURG, PH
[J]. EMBO JOURNAL, 1989, 8 (13) : 4025 - 4034
[4] THE GENOMIC CLONE G-21 WHICH RESEMBLES A BETA-ADRENERGIC-RECEPTOR SEQUENCE ENCODES THE 5-HT1A RECEPTOR
FARGIN, A
RAYMOND, JR
LOHSE, MJ
KOBILKA, BK
CARON, MG
LEFKOWITZ, RJ
[J]. NATURE, 1988, 335 (6188) : 358 - 360
[5] FOGUET M, IN PRESS EMBO J
[6] IDENTIFICATION OF MUTATIONS LEADING TO THE LESCH-NYHAN SYNDROME BY AUTOMATED DIRECT DNA SEQUENCING OF INVITRO AMPLIFIED CDNA
GIBBS, RA
NGUYEN, PN
MCBRIDE, LJ
KOEPF, SM
CASKEY, CT
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (06) : 1919 - 1923
[7] HERSHEY AD, 1991, J BIOL CHEM, V266, P4366
[8] 5-HT RECEPTORS - SUBTYPES AND 2ND MESSENGERS
HOYER, D
SCHOEFFTER, P
[J]. JOURNAL OF RECEPTOR RESEARCH, 1991, 11 (1-4): : 197 - 214
[9] THE 5HT2 RECEPTOR DEFINES A FAMILY OF STRUCTURALLY DISTINCT BUT FUNCTIONALLY CONSERVED SEROTONIN RECEPTORS
JULIUS, D
HUANG, KN
LIVELLI, TJ
AXEL, R
JESSELL, TM
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (03) : 928 - 932
[10] CDNA CLONING OF A SEROTONIN 5-HT1C RECEPTOR BY ELECTROPHYSIOLOGICAL ASSAYS OF MESSENGER RNA-INJECTED XENOPUS OOCYTES
LUBBERT, H
HOFFMAN, BJ
SNUTCH, TP
VANDYKE, T
LEVINE, AJ
HARTIG, PR
LESTER, HA
DAVIDSON, N
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (12) : 4332 - 4336

← 1 2 →