EFFECT OF LIPOSOMAL INTERLEUKIN-2 ON ASCITES-FORMING RAT HEPATOMA

被引:14
作者
KONNO, H
MARUO, Y
MATIN, AF
TANAKA, T
NAKAMURA, S
BABA, S
YAMASHITA, A
TADAKUMA, T
机构
[1] HAMAMATSU UNIV SCH MED, DEPT ANAT 2, HAMAMATSU, SHIZUOKA 43131, JAPAN
[2] KEIO UNIV, SCH MED, DEPT MICROBIOL, TOKYO 108, JAPAN
关键词
IL-2; LIPOSOMES; MACROPHAGES; TUMOR NECROSIS FACTOR; FREE RADICALS;
D O I
10.1002/jso.2930510110
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Interleukin-2 was entrapped in liposomes (Lip-IL-2) and injected into rats. The intraperitoneal injection of Lip-IL-2 into rats bearing an ascites-forming rat hepatoma (AH-66) significantly increased the survival time when compared with rats administered free IL-2 or saline-containing liposomes. The number of peritoneal excudate cells (PEC) increased markedly after intraperitoneal injection of Lip-IL-2 and consisted mainly of macrophages. The level of tumor necrosis factor alpha (TNF-alpha) and the intensity of free radicals increased in the ascites at 48 hrs after Lip-IL-2 administration, whereas TNF-alpha. was not detected and the intensity of free radicals did not increase after free IL-2 administration. Our findings suggested that entrapment of IL-2 into liposomes enhanced its potential for cancer therapy, presumably by activating macrophages to produce TNF-alpha and free radicals.
引用
收藏
页码:33 / 37
页数:5
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