COURSE AND SPONTANEOUS REGRESSION OF ACUTE-PANCREATITIS IN THE RAT

被引:175
作者
ADLER, G [1 ]
HUPP, T [1 ]
KERN, HF [1 ]
机构
[1] UNIV MARBURG,DEPT CELL BIOL & CELL PATHOL,D-3550 MARBURG,FED REP GER
关键词
Mitotic activity; Pancreatitis; Regeneration; Secretory process;
D O I
10.1007/BF01102739
中图分类号
R602 [外科病理学、解剖学]; R32 [人体形态学];
学科分类号
100101 ;
摘要
Rat exocrine pancreatic function was studied structurally and biochemically after the in vivo production of acute interstitial pancreatitis by supramaximal stimulation with caerulein. Two major phases in the reaction of the gland were observed: During the first two days after cessation of the supramaximal stimulation a progressive infiltration of the interstitium and the pancreatic tissue with polymorphonuclear leucocytes, lymphocytes and macrophages occurred which led to further destruction of the gland and to decreased functional response. From two days after the cessation of the treatment, hypertrophy of centro-acinar cells and an increased rate of mitotic activity indicated regeneration of the pancreas. This was combined with an accelerated in vitro discharge of newly synthesized proteins over a period of four days. Between days three and six after the initial treatment mitotic activity was also observed in fully differentiated exocrine cells. Total structural and functional recovery of the pancreas was achieved nine to twelve days after the cessation of the supramaximal stimulation. © 1979 Springer-Verlag.
引用
收藏
页码:31 / 47
页数:17
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