TISSUE-SPECIFICITY OF THE ENDOTHELIN-INDUCED RESPONSES

被引：46

作者：

MASAKI, T

机构：

[1] Department of Pharmacology, Faculty of Medicine, Kyoto University, Kyoto

来源：

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY | 1991年 / 17卷

关键词：

ENDOTHELIN; ENDOTHELIN RECEPTOR; CALCIUM CHANNEL; PHOSPHOLIPASE-C; PHOSPHOLIPASE-A2;

D O I：

10.1097/00005344-199100177-00002

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Endothelin (ET-1) has many activities in various tissues and organs. Even in the vascular system, ET-1 elicits vasodilation as well as vasoconstriction. These diverse responses induced by ET-1 are ascribed to the balance between ET-1 and ET-3 effects that are mediated by (a) at least two types of calcium channel activated by ET, (b) three distinct prototypes of ET-receptor subtypes, (c) the diversity of the intracellular signal transduction system, especially cyclooxygenase products, and (d) modulation of hormonal and neuronal factors.

引用

页码：S1 / S4

页数：4

共 39 条

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