ZIDOVUDINE-INDUCED BLOCKADE OF THE EXPRESSION AND FUNCTION OF THE ERYTHROPOIETIN RECEPTOR

被引：20

作者：

GOGU, SR

MALTER, JS

AGRAWAL, KC

机构：

[1] TULANE UNIV,SCH MED,DEPT PHARMACOL,NEW ORLEANS,LA 70112

[2] TULANE UNIV,SCH MED,DEPT PATHOL,NEW ORLEANS,LA 70112

来源：

BIOCHEMICAL PHARMACOLOGY | 1992年 / 44卷 / 06期

关键词：

D O I：

10.1016/0006-2952(92)90361-L

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Treatment of bone marrow progenitor cells (BMPC) with zidovudine (AZT) at various concentrations (0.5 to 20 muM) in vitro for 24 hr caused a concentration-dependent decrease in erythropoietin (Epo) receptor expression. The decrease in Epo receptors correlated with a decline in mRNA levels of the receptor. These results suggest that AZT-induced down-regulation of Epo receptor expression followed by loss of Epo-receptor mediated signal transduction is a significant contributory factor to AZT-induced erythroid toxicity.

引用

页码：1009 / 1012

页数：4

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