LEUKOCYTE CHEMOTACTIC ACTIVITY OF FKBP AND INHIBITION BY FK506

被引：24

作者：

LEIVA, MC ^{[1
]}

LYTTLE, CR ^{[1
]}

机构：

[1] UNIV PENN,DEPT OBSTET & GYNECOL,DIV REPROD BIOL,CLIN RES BLDG,RM 778,422 CURRIE BLVD,PHILADELPHIA,PA 19104

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1992年 / 186卷 / 02期

关键词：

D O I：

10.1016/0006-291X(92)90871-H

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cyclophilin, the cyclosporin A binding protein and member of the immunophilin family of proteins, demonstrates leukocyte chemotactic activity. In this study we demonstrate that FKBP, the FK506 and rapamycin binding protein, also displays leukocyte chemotactic activity. The chemotactic activity of FKBP is inhibited by FK506, however, FK506 was unable to inhibit cyclophilin-stimulated chemotactic activity. Rapamycin was unable to prevent the chemotactic activity of FKBP, similarly, the CsA analogue Me6Ala-CsA while displaying cyclophilin binding was unable to block cyclophilin-stimulated chemotactic activity. These results suggest that in addition to their intracellular role the immunophilins may also function as chemotactic agents, furthermore this activity is modulated by immunosuppressants. © 1992.

引用

页码：1178 / 1183

页数：6

共 34 条

[21] CLONING, EXPRESSION, AND PURIFICATION OF HUMAN CYCLOPHILIN IN ESCHERICHIA-COLI AND ASSESSMENT OF THE CATALYTIC ROLE OF CYSTEINES BY SITE-DIRECTED MUTAGENESIS [J].